T Xu1, Y Wang1, Z Li1, J Huang1, S S Y Lui1, S-P Tan2, X Yu3, E F C Cheung4, M-G He5, J Ott6, R E Gur7, R C Gur7, R C K Chan1. 1. Neuropsychology and Applied Cognitive Neuroscience Laboratory,Key Laboratory of Mental Health,Institute of Psychology,Chinese Academy of Sciences,Beijing,People's Republic of China. 2. Beijing Huilongguan Hospital,Beijing,People's Republic of China. 3. Peking University Sixth Hospital,Beijing,People's Republic of China. 4. Castle Peak Hospital,Hong Kong Special Administrative Region,People's Republic of China. 5. State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangzhou,People's Republic of China. 6. Statistical Genetics Laboratory,Key Laboratory of Mental Health,Institute of Psychology,Chinese Academy of Sciences,Beijing,People's Republic of China. 7. Department of Psychiatry,Perelman School of Medicine,University of Pennsylvania,and the Philadelphia Veterans Administration Medical Center,Philadelphia,PA,USA.
Abstract
BACKGROUND: Neurological soft signs (NSS) have long been considered potential endophenotypes for schizophrenia. However, few studies have investigated the heritability and familiality of NSS. The present study examined the heritability and familiality of NSS in healthy twins and patient-relative pairs. METHOD: The abridged version of the Cambridge Neurological Inventory was administered to 267 pairs of monozygotic twins, 124 pairs of dizygotic twins, and 75 pairs of patients with schizophrenia and their non-psychotic first-degree relatives. RESULTS: NSS were found to have moderate but significant heritability in the healthy twin sample. Moreover, patients with schizophrenia correlated closely with their first-degree relatives on NSS. CONCLUSIONS: Taken together, the findings provide evidence on the heritability and familiality of NSS in the Han Chinese population.
BACKGROUND: Neurological soft signs (NSS) have long been considered potential endophenotypes for schizophrenia. However, few studies have investigated the heritability and familiality of NSS. The present study examined the heritability and familiality of NSS in healthy twins and patient-relative pairs. METHOD: The abridged version of the Cambridge Neurological Inventory was administered to 267 pairs of monozygotic twins, 124 pairs of dizygotic twins, and 75 pairs of patients with schizophrenia and their non-psychotic first-degree relatives. RESULTS: NSS were found to have moderate but significant heritability in the healthy twin sample. Moreover, patients with schizophrenia correlated closely with their first-degree relatives on NSS. CONCLUSIONS: Taken together, the findings provide evidence on the heritability and familiality of NSS in the Han Chinese population.
Authors: Zhi Li; Jia Huang; Ting Xu; Ya Wang; Ke Li; Ya-Wei Zeng; Simon S Y Lui; Eric F C Cheung; Zhen Jin; Paola Dazzan; David C Glahn; Raymond C K Chan Journal: Hum Brain Mapp Date: 2017-12-19 Impact factor: 5.038
Authors: Paul G Nestor; Victoria Choate Hasler; Keira O'Donovan; Hannah E Lapp; Sara B Boodai; Richard Hunter Journal: Brain Behav Date: 2021-05-01 Impact factor: 2.708
Authors: Liliana Galindo; Daniel Bergé; Graham K Murray; Anna Mané; Antonio Bulbena; Victor Pérez; Oscar Vilarroya Journal: Front Psychiatry Date: 2018-01-08 Impact factor: 4.157