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Literature DB >> 2634666

The prevalence of avascular necrosis in sickle cell anemia: correlation with alpha-thalassemia.

S K Ballas¹, C A Talacki, V M Rao, R M Steiner.

Abstract

The purpose of the present study was to investigate the effect of alpha-thalassemia on the prevalence of avascular necrosis in 52 adult patients with sickle cell anemia. alpha-Globin genotypes were determined by restriction endonuclease mapping of genomic DNA extracted from peripheral blood leukocytes. Radiographs of humeral and femoral heads were interpreted by two radiologists who were not aware of the clinical picture and the genotype of the patients in the study. We present data showing that there is a significant positive correlation between alpha-gene deletion and the prevalence and extent of avascular necrosis in our patient population.

Entities: Disease Gene Species

Mesh：

Year: 1989 PMID： 2634666 DOI： 10.3109/03630268908998842

Source DB: PubMed Journal: Hemoglobin ISSN： 0363-0269 Impact factor: 0.849

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Cited

12 in total

1. Alpha thalassemia, but not β^S-globin haplotypes, influence sickle cell anemia clinical outcome in a large, single-center Brazilian cohort.

Authors: Betânia Lucena Domingues Hatzlhofer; Diego Antonio Pereira-Martins; Igor de Farias Domingos; Gabriela da Silva Arcanjo; Isabel Weinhäuser; Diego Arruda Falcão; Isabela Cristina Cordeiro Farias; Jéssica Vitória Gadelha de Freitas Batista; Luana Priscilla Laranjeira Prado; Jéssica Maria Florencio Oliveira; Thais Helena Chaves Batista; Marcondes José de Vasconcelos Costa Sobreira; Rodrigo Marcionilo de Santana; Amanda Bezerra de Sá Araújo; Manuela Albuquerque de Melo; Bruna Vasconcelos de Ancântara; Juan Luiz Coelho-Silva; Ana Beatriz Lucas de Moura Rafael; Danízia Menezes de Lima Silva; Flávia Peixoto Albuquerque; Magnun Nueldo Nunes Santos; Ana Cláudia Dos Anjos; Fernando Ferreira Costa; Aderson da Silva Araújo; Antonio Roberto Lucena-Araújo; Marcos André Cavalcanti Bezerra
Journal: Ann Hematol Date: 2021-02-13 Impact factor: 3.673

2. Does increased red blood cell deformability raise the risk for osteonecrosis in sickle cell anemia?

Authors: Nathalie Lemonne; Yann Lamarre; Marc Romana; Martin Mukisi-Mukaza; Marie-Dominique Hardy-Dessources; Vanessa Tarer; Danielle Mougenel; Xavier Waltz; Benoît Tressières; Marie-Laure Lalanne-Mistrih; Maryse Etienne-Julan; Philippe Connes
Journal: Blood Date: 2013-04-11 Impact factor: 22.113

Review 3. Knowledge insufficient: the management of haemoglobin SC disease.

Authors: Lydia H Pecker; Beverly A Schaefer; Lori Luchtman-Jones
Journal: Br J Haematol Date: 2016-12-16 Impact factor: 6.998

4. Association between sickle cell anemia and alpha thalassemia reveals a high prevalence of the α^3.7 triplication in congolese patients than in worldwide series.

Authors: Tite Minga Mikobi; Prosper Tshilobo Lukusa; Michel Ntetani Aloni; Aimé Lumaka; Pierre Zalagile Akilimali; Koenraad Devriendt; Gert Matthijs; Jean-Marie Mbuyi Muamba; Valerie Race
Journal: J Clin Lab Anal Date: 2017-03-09 Impact factor: 2.352

Review 5. Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes.

Authors: Gregory J Kato; Mark T Gladwin; Martin H Steinberg
Journal: Blood Rev Date: 2006-11-07 Impact factor: 8.250

The prevalence of avascular necrosis in sickle cell anemia: correlation with alpha-thalassemia.

1. Alpha thalassemia, but not β^S-globin haplotypes, influence sickle cell anemia clinical outcome in a large, single-center Brazilian cohort.

2. Does increased red blood cell deformability raise the risk for osteonecrosis in sickle cell anemia?

Review 3. Knowledge insufficient: the management of haemoglobin SC disease.

4. Association between sickle cell anemia and alpha thalassemia reveals a high prevalence of the α^3.7 triplication in congolese patients than in worldwide series.

Review 5. Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes.

Review 6. Beyond the definitions of the phenotypic complications of sickle cell disease: an update on management.

7. Multiple complications in a sickle cell disease patient: a case report.

8. Genotypic influence of α-deletions on the phenotype of Indian sickle cell anemia patients.

Review 9. Evolving locally appropriate models of care for indian sickle cell disease.

10. How I Treat Acute and Persistent Sickle Cell Pain.

The prevalence of avascular necrosis in sickle cell anemia: correlation with alpha-thalassemia.

1. Alpha thalassemia, but not βS-globin haplotypes, influence sickle cell anemia clinical outcome in a large, single-center Brazilian cohort.

2. Does increased red blood cell deformability raise the risk for osteonecrosis in sickle cell anemia?

Review 3. Knowledge insufficient: the management of haemoglobin SC disease.

4. Association between sickle cell anemia and alpha thalassemia reveals a high prevalence of the α3.7 triplication in congolese patients than in worldwide series.

Review 5. Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes.

Review 6. Beyond the definitions of the phenotypic complications of sickle cell disease: an update on management.

7. Multiple complications in a sickle cell disease patient: a case report.

8. Genotypic influence of α-deletions on the phenotype of Indian sickle cell anemia patients.

Review 9. Evolving locally appropriate models of care for indian sickle cell disease.

10. How I Treat Acute and Persistent Sickle Cell Pain.

1. Alpha thalassemia, but not β^S-globin haplotypes, influence sickle cell anemia clinical outcome in a large, single-center Brazilian cohort.

4. Association between sickle cell anemia and alpha thalassemia reveals a high prevalence of the α^3.7 triplication in congolese patients than in worldwide series.