Jhong-Lin Wu1, Hsuan-Yin Ma1, Chun-Yi Lu1, Jong-Min Chen1, Ping-Ing Lee1, Shiann-Tarng Jou2, Yung-Lin Yang2, Hsiu-Hao Chang2, Meng-Yao Lu2, Luan-Ying Chang3, Li-Min Huang1. 1. Division of Infectious Disease, Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taiwan, ROC. 2. Division of Hematology-Oncology, Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taiwan, ROC. 3. Division of Infectious Disease, Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taiwan, ROC. Electronic address: ly7077@tpts6.seed.net.tw.
Abstract
BACKGROUND: Cytomegalovirus (CMV) is a major pathogen causing significant mortality and morbidity in immunocompromised hosts. It is important to find risk factors associated with CMV viremia and its outcome. METHODS: We investigated the incidence, time of onset, risk factors for CMV viremia, and characteristics of CMV diseases in 57 pediatric patients receiving hematopoietic stem cell transplantation (HSCT). Between August 2011 and March 2014, cases of pediatric HSCT patients at the National Taiwan University Children's Hospital were reviewed. Viremia was identified by plasma CMV real-time polymerase chain reaction (RT-PCR) assay. RESULTS: Eighteen (32%) of the 57 patients developed CMV viremia at a median of 23 days post-HSCT (range -3 to +721 days). Eighty-nine percent (16/18) of CMV viremia occurred within 100 days posttransplantation. Four patients finally had CMV diseases (1 with CMV colitis and 3 with CMV pneumonitis) and one patient died of CMV pneumonitis complicated with pulmonary hemorrhage and sepsis. Significant risk factors associated with CMV viremia via univariate analysis include older age (p = 0.03), leukemic patients [odds ratio (OR): 5.2, 95% confidence interval (CI): 1.52∼17.7, p = 0.008), allogeneic HSCT (OR: 14.57, 95% CI: 1.76∼120.5, p = 0.002), antithymoglobulin (ATG) use before transplantation (OR: 5.09, 95% CI: 1.52∼16.9, p = 0.007), graft-versus-host disease (GvHD) (OR: 10.1, 95% CI: 2.7∼38.7, p < 0.001), and gastrointestinal GvHD (OR: 10.9, 95% CI: 2.72∼43.9, p = 0.001). CONCLUSION: In pediatric posttransplantation patients, CMV viremia mostly occurred within 100 days after transplantation. Risk factors associated with CMV viremia include older diagnostic age, leukemic patients, unrelated donor HSCT, pretransplant ATG use, GvHD, and gastrointestinal GvHD.
BACKGROUND: Cytomegalovirus (CMV) is a major pathogen causing significant mortality and morbidity in immunocompromised hosts. It is important to find risk factors associated with CMV viremia and its outcome. METHODS: We investigated the incidence, time of onset, risk factors for CMV viremia, and characteristics of CMV diseases in 57 pediatric patients receiving hematopoietic stem cell transplantation (HSCT). Between August 2011 and March 2014, cases of pediatric HSCT patients at the National Taiwan University Children's Hospital were reviewed. Viremia was identified by plasma CMV real-time polymerase chain reaction (RT-PCR) assay. RESULTS: Eighteen (32%) of the 57 patients developed CMV viremia at a median of 23 days post-HSCT (range -3 to +721 days). Eighty-nine percent (16/18) of CMV viremia occurred within 100 days posttransplantation. Four patients finally had CMV diseases (1 with CMV colitis and 3 with CMV pneumonitis) and one patient died of CMV pneumonitis complicated with pulmonary hemorrhage and sepsis. Significant risk factors associated with CMV viremia via univariate analysis include older age (p = 0.03), leukemicpatients [odds ratio (OR): 5.2, 95% confidence interval (CI): 1.52∼17.7, p = 0.008), allogeneic HSCT (OR: 14.57, 95% CI: 1.76∼120.5, p = 0.002), antithymoglobulin (ATG) use before transplantation (OR: 5.09, 95% CI: 1.52∼16.9, p = 0.007), graft-versus-host disease (GvHD) (OR: 10.1, 95% CI: 2.7∼38.7, p < 0.001), and gastrointestinal GvHD (OR: 10.9, 95% CI: 2.72∼43.9, p = 0.001). CONCLUSION: In pediatric posttransplantation patients, CMV viremia mostly occurred within 100 days after transplantation. Risk factors associated with CMV viremia include older diagnostic age, leukemicpatients, unrelated donor HSCT, pretransplant ATG use, GvHD, and gastrointestinal GvHD.
Authors: Alberto Busmail; Sai Sri Penumetcha; Saher Ahluwalia; Rejja Irfan; Sawleha Arshi Khan; Sai Rohit Reddy; Maria Elisa Vasquez Lopez; Maryam Zahid; Lubna Mohammed Journal: Cureus Date: 2022-05-07
Authors: Eirini Mavropoulou; Kristin Ternes; Nicolae-Catalin Mechie; Sebastian Christopher Benjamin Bremer; Steffen Kunsch; Volker Ellenrieder; Albrecht Neesse; Ahmad Amanzada Journal: BMJ Open Gastroenterol Date: 2019-02-27
Authors: Sarah M Heston; Rebecca R Young; John S Tanaka; Kirsten Jenkins; Richard Vinesett; Frances M Saccoccio; Paul L Martin; Nelson J Chao; Matthew S Kelly Journal: Open Forum Infect Dis Date: 2021-12-16 Impact factor: 3.835