Isabelle Audo1,2,3,4,5, Kiyoko Gocho6,7, Florence Rossant8, Saddek Mohand-Saïd6,9,10,11, Kevin Loquin12, Isabelle Bloch13, José-Alain Sahel6,9,10,11,12,14, Michel Paques6,9,10,11. 1. Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, DHU View Maintain, INSERM-DHOS CIC 1423, Paris, 75012, France. isabelle.audo@inserm.fr. 2. INSERM, U968, Paris, 75012, France. isabelle.audo@inserm.fr. 3. Institut de la Vision, Sorbonne Universités, UPMC Univ Paris 06, UMR_S 968, Paris, 75012, France. isabelle.audo@inserm.fr. 4. CNRS, UMR_7210, Paris, 75012, France. isabelle.audo@inserm.fr. 5. Département de Génétique, Curie/CHNO des Quinze-Vingts, Centre de Recherche Institut de la Vision, UMR S 968 Inserm / Université Pierre et Marie, 17, rue Moreau, 75012, Paris, France. isabelle.audo@inserm.fr. 6. Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, DHU View Maintain, INSERM-DHOS CIC 1423, Paris, 75012, France. 7. Ophthalmology, Nippon Medical University, Chiba Hokusoh Hospital, Inzai, Japan. 8. Institut Supérieur d'Electronique de Paris, Paris, France. 9. INSERM, U968, Paris, 75012, France. 10. Institut de la Vision, Sorbonne Universités, UPMC Univ Paris 06, UMR_S 968, Paris, 75012, France. 11. CNRS, UMR_7210, Paris, 75012, France. 12. Fondation Ophtalmologique Adolphe de Rothschild, Paris, France. 13. Telecom Paris Tech, CNRS LTCI, Paris, France. 14. Académie des Sciences-Institut de France, Paris, 75006, France.
Abstract
BACKGROUND: To report functional and high-resolution retinal imaging abnormalities, including adaptive optics (AO) throughout the course of acute macular neuroretinopathy (AMNR). METHODS: Two female patients (four eyes) with a diagnosis of AMNR were observed at the Clinical Investigation Center, CHNO des Quinze-Vingts, Paris, France. The patients underwent detailed ophthalmic examination including best-corrected visual acuity, slit-lamp examination, kinetic and static perimetry, full-field and multifocal electroretinogram, infrared reflectance, autofluorescence imaging and spectral-domain optical coherence tomography (SD-OCT) and AO fundus imaging at presentation and during follow-up. RESULTS: Both cases showed concomitant loss of integrity of the outer retinal structures on SD-OCT, and marked abnormalities on AO imaging with disruption of the visibility of the cone mosaic. In the first case, photoreceptor damage was seen to progress during several weeks before healing. In both cases, there were persistent morphological abnormalities of photoreceptors 1 year after onset. CONCLUSION: This study further highlights the value of AO fundus imaging to facilitate detection, mapping, and monitoring of damage to the cone outer segments during AMNR. In particular, residual damage to the cone mosaic can be precisely documented.
BACKGROUND: To report functional and high-resolution retinal imaging abnormalities, including adaptive optics (AO) throughout the course of acute macular neuroretinopathy (AMNR). METHODS: Two female patients (four eyes) with a diagnosis of AMNR were observed at the Clinical Investigation Center, CHNO des Quinze-Vingts, Paris, France. The patients underwent detailed ophthalmic examination including best-corrected visual acuity, slit-lamp examination, kinetic and static perimetry, full-field and multifocal electroretinogram, infrared reflectance, autofluorescence imaging and spectral-domain optical coherence tomography (SD-OCT) and AO fundus imaging at presentation and during follow-up. RESULTS: Both cases showed concomitant loss of integrity of the outer retinal structures on SD-OCT, and marked abnormalities on AO imaging with disruption of the visibility of the cone mosaic. In the first case, photoreceptor damage was seen to progress during several weeks before healing. In both cases, there were persistent morphological abnormalities of photoreceptors 1 year after onset. CONCLUSION: This study further highlights the value of AO fundus imaging to facilitate detection, mapping, and monitoring of damage to the cone outer segments during AMNR. In particular, residual damage to the cone mosaic can be precisely documented.
Authors: Marion R Munk; Marco Beck; Simone Kolb; Michael Larsen; Steffen Hamann; Christophe Valmaggia; Martin S Zinkernagel Journal: Br J Ophthalmol Date: 2016-05-11 Impact factor: 4.638
Authors: Joanna H Tu; Katharina G Foote; Brandon J Lujan; Kavitha Ratnam; Jia Qin; Michael B Gorin; Emmett T Cunningham; William S Tuten; Jacque L Duncan; Austin Roorda Journal: Am J Ophthalmol Case Rep Date: 2017-04-12