| Literature DB >> 26344385 |
R Buchi Reddy1, Kishor R More2, Leena Gupta1, Mukesh S Jha1, Laki Magar1.
Abstract
A new unknown impurity was observed in accelerated stability studies of Metoprolol tartrate tablets. This impurity has been identified, synthesized and characterized through different spectral studies and confirmed as an adduct of lactose and Metoprolol formed by Maillard reaction.Entities:
Keywords: Amadori rearrangement; Lactose; Maillard; Metoprolol; Stability
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Year: 2015 PMID： 26344385 DOI： 10.1016/j.jpba.2015.08.039
Source DB: PubMed Journal: J Pharm Biomed Anal ISSN： 0731-7085 Impact factor: 3.935