Literature DB >> 26343811

Reduced cerebrospinal fluid mitochondrial DNA is a biomarker for early-stage Parkinson's disease.

Angela Pyle1, Rebecca Brennan1, Marzena Kurzawa-Akanbi1, Alison Yarnall2, Anais Thouin2, Brit Mollenhauer3, David Burn2, Patrick F Chinnery1, Gavin Hudson1.   

Abstract

The identification of cell-free circulating mitochondrial DNA (ccf-mtDNA) in early-stage Alzheimer's disease (AD) raised the possibility that the same neurodegenerative effect could be observed in Parkinson's disease (PD). Here, and for the first time, we investigated the role of ccf-mtDNA in PD, identifying a significant reduction of ccf-mtDNA in PD patient cerebrospinal fluid (CSF) when compared to controls. Our data demonstrates that CSF ccf-mtDNA is not only a powerful biomarker for PD, but, given that the effect is also observed in AD, is likely a biomarker for neurodegeneration.
© 2015 American Neurological Association.

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Year:  2015        PMID： 26343811      PMCID： PMC6551217          DOI： 10.1002/ana.24515

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  26 in total

1.  Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease.

Authors:  Baiyang Sheng; Xinglong Wang; Bo Su; Hyoung-gon Lee; Gemma Casadesus; George Perry; Xiongwei Zhu
Journal:  J Neurochem       Date:  2011-12-08       Impact factor: 5.372

Review 2.  Parkinson's disease: clinical features and diagnosis.

Authors:  J Jankovic
Journal:  J Neurol Neurosurg Psychiatry       Date:  2008-04       Impact factor: 10.154

3.  The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment.

Authors:  Ziad S Nasreddine; Natalie A Phillips; Valérie Bédirian; Simon Charbonneau; Victor Whitehead; Isabelle Collin; Jeffrey L Cummings; Howard Chertkow
Journal:  J Am Geriatr Soc       Date:  2005-04       Impact factor: 5.562

4.  A clinico-pathological study of subtypes in Parkinson's disease.

Authors:  M Selikhova; D R Williams; P A Kempster; J L Holton; T Revesz; A J Lees
Journal:  Brain       Date:  2009-09-16       Impact factor: 13.501

5.  Circulating mitochondrial DAMPs cause inflammatory responses to injury.

Authors:  Qin Zhang; Mustafa Raoof; Yu Chen; Yuka Sumi; Tolga Sursal; Wolfgang Junger; Karim Brohi; Kiyoshi Itagaki; Carl J Hauser
Journal:  Nature       Date:  2010-03-04       Impact factor: 49.962

6.  Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.

Authors:  A J Hughes; S E Daniel; L Kilford; A J Lees
Journal:  J Neurol Neurosurg Psychiatry       Date:  1992-03       Impact factor: 10.154

7.  Effects of rivastigmine on cognitive function in dementia with lewy bodies: a randomised placebo-controlled international study using the cognitive drug research computerised assessment system.

Authors:  K A Wesnes; I G McKeith; R Ferrara; M Emre; T Del Ser; P F Spano; A Cicin-Sain; R Anand; R Spiegel
Journal:  Dement Geriatr Cogn Disord       Date:  2002       Impact factor: 2.959

8.  ALS spinal neurons show varied and reduced mtDNA gene copy numbers and increased mtDNA gene deletions.

Authors:  Paula M Keeney; James P Bennett
Journal:  Mol Neurodegener       Date:  2010-05-26       Impact factor: 14.195

9.  A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking.

Authors:  C E Teunissen; A Petzold; J L Bennett; F S Berven; L Brundin; M Comabella; D Franciotta; J L Frederiksen; J O Fleming; R Furlan; R Q Hintzen; S G Hughes; M H Johnson; E Krasulova; J Kuhle; M C Magnone; C Rajda; K Rejdak; H K Schmidt; V van Pesch; E Waubant; C Wolf; G Giovannoni; B Hemmer; H Tumani; F Deisenhammer
Journal:  Neurology       Date:  2009-12-01       Impact factor: 9.910

10.  Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors.

Authors:  Corina Kohler; Ramin Radpour; Zeinab Barekati; Reza Asadollahi; Johannes Bitzer; Edward Wight; Nicole Bürki; Claude Diesch; Wolfgang Holzgreve; Xiao Yan Zhong
Journal:  Mol Cancer       Date:  2009-11-17       Impact factor: 27.401
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  40 in total

Review 1.  The unresolved role of mitochondrial DNA in Parkinson's disease: An overview of published studies, their limitations, and future prospects.

Authors:  Amica C Müller-Nedebock; Rebecca R Brennan; Marianne Venter; Ilse S Pienaar; Francois H van der Westhuizen; Joanna L Elson; Owen A Ross; Soraya Bardien
Journal:  Neurochem Int       Date:  2019-06-21       Impact factor: 3.921

2.  Increased cell-free mitochondrial DNA is a marker of ongoing inflammation and better neurocognitive function in virologically suppressed HIV-infected individuals.

Authors:  Josué Pérez-Santiago; Michelli F De Oliveira; Susanna R Var; Tyler R C Day; Steven P Woods; Sara Gianella; Sanjay R Mehta
Journal:  J Neurovirol       Date:  2016-12-05       Impact factor: 2.643

3.  Analytics of Cerebrospinal Fluid MicroRNA Quantitative PCR Studies.

Authors:  Theresa A Lusardi; Jack T Wiedrick; Molly Malone; Jay I Phillips; Ursula S Sandau; Babett Lind; Joseph F Quinn; Jodi A Lapidus; Julie A Saugstad
Journal:  Mol Neurobiol       Date:  2018-11-14       Impact factor: 5.590

Review 4.  Targeting Mitochondria as a Therapeutic Approach for Parkinson's Disease.

Authors:  Maryam Abrishamdar; Maryam Sadat Jalali; Yaghoob Farbood
Journal:  Cell Mol Neurobiol       Date:  2022-08-11       Impact factor: 4.231

Review 5.  The role of mitochondria in rheumatic diseases.

Authors:  Yann L C Becker; Bhargavi Duvvuri; Paul R Fortin; Christian Lood; Eric Boilard
Journal:  Nat Rev Rheumatol       Date:  2022-09-29       Impact factor: 32.286

Review 6.  Mitochondrial DNA copy number in human disease: the more the better?

Authors:  Roberta Filograna; Mara Mennuni; David Alsina; Nils-Göran Larsson
Journal:  FEBS Lett       Date:  2020-12-25       Impact factor: 4.124

7.  Serum FGF-21, GDF-15, and blood mtDNA copy number are not biomarkers of Parkinson disease.

Authors:  Ryan L Davis; Siew L Wong; Phillippa J Carling; Thomas Payne; Carolyn M Sue; Oliver Bandmann
Journal:  Neurol Clin Pract       Date:  2020-02

Review 8.  Extracellular Vesicles: Potential Mediators of Psychosocial Stress Contribution to Osteoporosis?

Authors:  Yangyang He; Karin Wuertz-Kozak; Linn K Kuehl; Pia-Maria Wippert
Journal:  Int J Mol Sci       Date:  2021-05-29       Impact factor: 5.923

Review 9.  Evidence for the Role of Mitochondrial DNA Release in the Inflammatory Response in Neurological Disorders.

Authors:  Gonzalo E Moya; Phillip D Rivera; Kristin E Dittenhafer-Reed
Journal:  Int J Mol Sci       Date:  2021-06-29       Impact factor: 5.923

10.  A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients.

Authors:  Cláudia M Deus; Susana P Pereira; Teresa Cunha-Oliveira; José Teixeira; Rui F Simões; Fernando Cagide; Sofia Benfeito; Fernanda Borges; Nuno Raimundo; Paulo J Oliveira
Journal:  Redox Biol       Date:  2021-06-08       Impact factor: 11.799
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