Literature DB >> 26343388

Class II HLA interactions modulate genetic risk for multiple sclerosis.

Loukas Moutsianas1, Luke Jostins1, Ashley H Beecham2, Alexander T Dilthey1, Dionysia K Xifara1, Maria Ban3, Tejas S Shah4, Nikolaos A Patsopoulos5,6,7,8, Lars Alfredsson9, Carl A Anderson4, Katherine E Attfield10, Sergio E Baranzini11, Jeffrey Barrett4, Thomas M C Binder12, David Booth13, Dorothea Buck14, Elisabeth G Celius15, Chris Cotsapas8,16,17, Sandra D'Alfonso18, Calliope A Dendrou19, Peter Donnelly1, Bénédicte Dubois20, Bertrand Fontaine21, Lars Fugger10,19, An Goris20, Pierre-Antoine Gourraud11, Christiane Graetz22, Bernhard Hemmer14,23,24, Jan Hillert25, Ingrid Kockum25, Stephen Leslie26,27, Christina M Lill22,28, Filippo Martinelli-Boneschi29,30, Jorge R Oksenberg11, Tomas Olsson25, Annette Oturai31, Janna Saarela32, Helle Bach Søndergaard31, Anne Spurkland33, Bruce Taylor34, Juliane Winkelmann14,23,35,36,37, Frauke Zipp22, Jonathan L Haines38, Margaret A Pericak-Vance2, Chris C A Spencer1, Graeme Stewart13, David A Hafler8,16,39, Adrian J Ivinson40, Hanne F Harbo15,41, Stephen L Hauser11, Philip L De Jager5,6,7,8, Alastair Compston3, Jacob L McCauley2, Stephen Sawcer3, Gil McVean1.   

Abstract

Association studies have greatly refined the understanding of how variation within the human leukocyte antigen (HLA) genes influences risk of multiple sclerosis. However, the extent to which major effects are modulated by interactions is poorly characterized. We analyzed high-density SNP data on 17,465 cases and 30,385 controls from 11 cohorts of European ancestry, in combination with imputation of classical HLA alleles, to build a high-resolution map of HLA genetic risk and assess the evidence for interactions involving classical HLA alleles. Among new and previously identified class II risk alleles (HLA-DRB1*15:01, HLA-DRB1*13:03, HLA-DRB1*03:01, HLA-DRB1*08:01 and HLA-DQB1*03:02) and class I protective alleles (HLA-A*02:01, HLA-B*44:02, HLA-B*38:01 and HLA-B*55:01), we find evidence for two interactions involving pairs of class II alleles: HLA-DQA1*01:01-HLA-DRB1*15:01 and HLA-DQB1*03:01-HLA-DQB1*03:02. We find no evidence for interactions between classical HLA alleles and non-HLA risk-associated variants and estimate a minimal effect of polygenic epistasis in modulating major risk alleles.

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Year:  2015        PMID： 26343388      PMCID： PMC4874245          DOI： 10.1038/ng.3395

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  35 in total

1.  Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis.

Authors:  Serena Sanna; Maristella Pitzalis; Magdalena Zoledziewska; Ilenia Zara; Carlo Sidore; Raffaele Murru; Michael B Whalen; Fabio Busonero; Andrea Maschio; Gianna Costa; Maria Cristina Melis; Francesca Deidda; Fausto Poddie; Laura Morelli; Gabriele Farina; Yun Li; Mariano Dei; Sandra Lai; Antonella Mulas; Gianmauro Cuccuru; Eleonora Porcu; Liming Liang; Patrizia Zavattari; Loredana Moi; Elisa Deriu; M Francesca Urru; Michele Bajorek; Maria Anna Satta; Eleonora Cocco; Paola Ferrigno; Stefano Sotgiu; Maura Pugliatti; Sebastiano Traccis; Andrea Angius; Maurizio Melis; Giulio Rosati; Gonçalo R Abecasis; Manuela Uda; Maria Giovanna Marrosu; David Schlessinger; Francesco Cucca
Journal:  Nat Genet       Date:  2010-05-09       Impact factor: 38.330

2.  GCTA: a tool for genome-wide complex trait analysis.

Authors:  Jian Yang; S Hong Lee; Michael E Goddard; Peter M Visscher
Journal:  Am J Hum Genet       Date:  2010-12-17       Impact factor: 11.025

3.  HLA*IMP--an integrated framework for imputing classical HLA alleles from SNP genotypes.

Authors:  Alexander T Dilthey; Loukas Moutsianas; Stephen Leslie; Gil McVean
Journal:  Bioinformatics       Date:  2011-02-07       Impact factor: 6.937

4.  Smoking and two human leukocyte antigen genes interact to increase the risk for multiple sclerosis.

Authors:  Anna Karin Hedström; Emilie Sundqvist; Maria Bäärnhielm; Nina Nordin; Jan Hillert; Ingrid Kockum; Tomas Olsson; Lars Alfredsson
Journal:  Brain       Date:  2011-02-08       Impact factor: 13.501

5.  Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.

Authors:  Sergio E Baranzini; Joanne Wang; Rachel A Gibson; Nicholas Galwey; Yvonne Naegelin; Frederik Barkhof; Ernst-Wilhelm Radue; Raija L P Lindberg; Bernard M G Uitdehaag; Michael R Johnson; Aspasia Angelakopoulou; Leslie Hall; Jill C Richardson; Rab K Prinjha; Achim Gass; Jeroen J G Geurts; Jolijn Kragt; Madeleine Sombekke; Hugo Vrenken; Pamela Qualley; Robin R Lincoln; Refujia Gomez; Stacy J Caillier; Michaela F George; Hourieh Mousavi; Rosa Guerrero; Darin T Okuda; Bruce A C Cree; Ari J Green; Emmanuelle Waubant; Douglas S Goodin; Daniel Pelletier; Paul M Matthews; Stephen L Hauser; Ludwig Kappos; Chris H Polman; Jorge R Oksenberg
Journal:  Hum Mol Genet       Date:  2008-11-14       Impact factor: 6.150

6.  A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

Authors:  Amy Strange; Francesca Capon; Chris C A Spencer; Jo Knight; Michael E Weale; Michael H Allen; Anne Barton; Gavin Band; Céline Bellenguez; Judith G M Bergboer; Jenefer M Blackwell; Elvira Bramon; Suzannah J Bumpstead; Juan P Casas; Michael J Cork; Aiden Corvin; Panos Deloukas; Alexander Dilthey; Audrey Duncanson; Sarah Edkins; Xavier Estivill; Oliver Fitzgerald; Colin Freeman; Emiliano Giardina; Emma Gray; Angelika Hofer; Ulrike Hüffmeier; Sarah E Hunt; Alan D Irvine; Janusz Jankowski; Brian Kirby; Cordelia Langford; Jesús Lascorz; Joyce Leman; Stephen Leslie; Lotus Mallbris; Hugh S Markus; Christopher G Mathew; W H Irwin McLean; Ross McManus; Rotraut Mössner; Loukas Moutsianas; Asa T Naluai; Frank O Nestle; Giuseppe Novelli; Alexandros Onoufriadis; Colin N A Palmer; Carlo Perricone; Matti Pirinen; Robert Plomin; Simon C Potter; Ramon M Pujol; Anna Rautanen; Eva Riveira-Munoz; Anthony W Ryan; Wolfgang Salmhofer; Lena Samuelsson; Stephen J Sawcer; Joost Schalkwijk; Catherine H Smith; Mona Ståhle; Zhan Su; Rachid Tazi-Ahnini; Heiko Traupe; Ananth C Viswanathan; Richard B Warren; Wolfgang Weger; Katarina Wolk; Nicholas Wood; Jane Worthington; Helen S Young; Patrick L J M Zeeuwen; Adrian Hayday; A David Burden; Christopher E M Griffiths; Juha Kere; André Reis; Gilean McVean; David M Evans; Matthew A Brown; Jonathan N Barker; Leena Peltonen; Peter Donnelly; Richard C Trembath
Journal:  Nat Genet       Date:  2010-10-17       Impact factor: 38.330

7.  Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.

Authors:  David M Evans; Chris C A Spencer; Jennifer J Pointon; Zhan Su; David Harvey; Grazyna Kochan; Udo Oppermann; Udo Opperman; Alexander Dilthey; Matti Pirinen; Millicent A Stone; Louise Appleton; Loukas Moutsianas; Loukas Moutsianis; Stephen Leslie; Tom Wordsworth; Tony J Kenna; Tugce Karaderi; Gethin P Thomas; Michael M Ward; Michael H Weisman; Claire Farrar; Linda A Bradbury; Patrick Danoy; Robert D Inman; Walter Maksymowych; Dafna Gladman; Proton Rahman; Ann Morgan; Helena Marzo-Ortega; Paul Bowness; Karl Gaffney; J S Hill Gaston; Malcolm Smith; Jacome Bruges-Armas; Ana-Rita Couto; Rosa Sorrentino; Fabiana Paladini; Manuel A Ferreira; Huji Xu; Yu Liu; Lei Jiang; Carlos Lopez-Larrea; Roberto Díaz-Peña; Antonio López-Vázquez; Tetyana Zayats; Gavin Band; Céline Bellenguez; Hannah Blackburn; Jenefer M Blackwell; Elvira Bramon; Suzannah J Bumpstead; Juan P Casas; Aiden Corvin; Nicholas Craddock; Panos Deloukas; Serge Dronov; Audrey Duncanson; Sarah Edkins; Colin Freeman; Matthew Gillman; Emma Gray; Rhian Gwilliam; Naomi Hammond; Sarah E Hunt; Janusz Jankowski; Alagurevathi Jayakumar; Cordelia Langford; Jennifer Liddle; Hugh S Markus; Christopher G Mathew; Owen T McCann; Mark I McCarthy; Colin N A Palmer; Leena Peltonen; Robert Plomin; Simon C Potter; Anna Rautanen; Radhi Ravindrarajah; Michelle Ricketts; Nilesh Samani; Stephen J Sawcer; Amy Strange; Richard C Trembath; Ananth C Viswanathan; Matthew Waller; Paul Weston; Pamela Whittaker; Sara Widaa; Nicholas W Wood; Gilean McVean; John D Reveille; B Paul Wordsworth; Matthew A Brown; Peter Donnelly
Journal:  Nat Genet       Date:  2011-07-10       Impact factor: 38.330

8.  A polymorphism in the HLA-DPB1 gene is associated with susceptibility to multiple sclerosis.

Authors:  Judith Field; Sharon R Browning; Laura J Johnson; Patrick Danoy; Michael D Varney; Brian D Tait; Kaushal S Gandhi; Jac C Charlesworth; Robert N Heard; Graeme J Stewart; Trevor J Kilpatrick; Simon J Foote; Melanie Bahlo; Helmut Butzkueven; James Wiley; David R Booth; Bruce V Taylor; Matthew A Brown; Justin P Rubio; Jim Stankovich
Journal:  PLoS One       Date:  2010-10-26       Impact factor: 3.240

9.  Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Authors:  Stephen Sawcer; Garrett Hellenthal; Matti Pirinen; Chris C A Spencer; Nikolaos A Patsopoulos; Loukas Moutsianas; Alexander Dilthey; Zhan Su; Colin Freeman; Sarah E Hunt; Sarah Edkins; Emma Gray; David R Booth; Simon C Potter; An Goris; Gavin Band; Annette Bang Oturai; Amy Strange; Janna Saarela; Céline Bellenguez; Bertrand Fontaine; Matthew Gillman; Bernhard Hemmer; Rhian Gwilliam; Frauke Zipp; Alagurevathi Jayakumar; Roland Martin; Stephen Leslie; Stanley Hawkins; Eleni Giannoulatou; Sandra D'alfonso; Hannah Blackburn; Filippo Martinelli Boneschi; Jennifer Liddle; Hanne F Harbo; Marc L Perez; Anne Spurkland; Matthew J Waller; Marcin P Mycko; Michelle Ricketts; Manuel Comabella; Naomi Hammond; Ingrid Kockum; Owen T McCann; Maria Ban; Pamela Whittaker; Anu Kemppinen; Paul Weston; Clive Hawkins; Sara Widaa; John Zajicek; Serge Dronov; Neil Robertson; Suzannah J Bumpstead; Lisa F Barcellos; Rathi Ravindrarajah; Roby Abraham; Lars Alfredsson; Kristin Ardlie; Cristin Aubin; Amie Baker; Katharine Baker; Sergio E Baranzini; Laura Bergamaschi; Roberto Bergamaschi; Allan Bernstein; Achim Berthele; Mike Boggild; Jonathan P Bradfield; David Brassat; Simon A Broadley; Dorothea Buck; Helmut Butzkueven; Ruggero Capra; William M Carroll; Paola Cavalla; Elisabeth G Celius; Sabine Cepok; Rosetta Chiavacci; Françoise Clerget-Darpoux; Katleen Clysters; Giancarlo Comi; Mark Cossburn; Isabelle Cournu-Rebeix; Mathew B Cox; Wendy Cozen; Bruce A C Cree; Anne H Cross; Daniele Cusi; Mark J Daly; Emma Davis; Paul I W de Bakker; Marc Debouverie; Marie Beatrice D'hooghe; Katherine Dixon; Rita Dobosi; Bénédicte Dubois; David Ellinghaus; Irina Elovaara; Federica Esposito; Claire Fontenille; Simon Foote; Andre Franke; Daniela Galimberti; Angelo Ghezzi; Joseph Glessner; Refujia Gomez; Olivier Gout; Colin Graham; Struan F A Grant; Franca Rosa Guerini; Hakon Hakonarson; Per Hall; Anders Hamsten; Hans-Peter Hartung; Rob N Heard; Simon Heath; Jeremy Hobart; Muna Hoshi; Carmen Infante-Duarte; Gillian Ingram; Wendy Ingram; Talat Islam; Maja Jagodic; Michael Kabesch; Allan G Kermode; Trevor J Kilpatrick; Cecilia Kim; Norman Klopp; Keijo Koivisto; Malin Larsson; Mark Lathrop; Jeannette S Lechner-Scott; Maurizio A Leone; Virpi Leppä; Ulrika Liljedahl; Izaura Lima Bomfim; Robin R Lincoln; Jenny Link; Jianjun Liu; Aslaug R Lorentzen; Sara Lupoli; Fabio Macciardi; Thomas Mack; Mark Marriott; Vittorio Martinelli; Deborah Mason; Jacob L McCauley; Frank Mentch; Inger-Lise Mero; Tania Mihalova; Xavier Montalban; John Mottershead; Kjell-Morten Myhr; Paola Naldi; William Ollier; Alison Page; Aarno Palotie; Jean Pelletier; Laura Piccio; Trevor Pickersgill; Fredrik Piehl; Susan Pobywajlo; Hong L Quach; Patricia P Ramsay; Mauri Reunanen; Richard Reynolds; John D Rioux; Mariaemma Rodegher; Sabine Roesner; Justin P Rubio; Ina-Maria Rückert; Marco Salvetti; Erika Salvi; Adam Santaniello; Catherine A Schaefer; Stefan Schreiber; Christian Schulze; Rodney J Scott; Finn Sellebjerg; Krzysztof W Selmaj; David Sexton; Ling Shen; Brigid Simms-Acuna; Sheila Skidmore; Patrick M A Sleiman; Cathrine Smestad; Per Soelberg Sørensen; Helle Bach Søndergaard; Jim Stankovich; Richard C Strange; Anna-Maija Sulonen; Emilie Sundqvist; Ann-Christine Syvänen; Francesca Taddeo; Bruce Taylor; Jenefer M Blackwell; Pentti Tienari; Elvira Bramon; Ayman Tourbah; Matthew A Brown; Ewa Tronczynska; Juan P Casas; Niall Tubridy; Aiden Corvin; Jane Vickery; Janusz Jankowski; Pablo Villoslada; Hugh S Markus; Kai Wang; Christopher G Mathew; James Wason; Colin N A Palmer; H-Erich Wichmann; Robert Plomin; Ernest Willoughby; Anna Rautanen; Juliane Winkelmann; Michael Wittig; Richard C Trembath; Jacqueline Yaouanq; Ananth C Viswanathan; Haitao Zhang; Nicholas W Wood; Rebecca Zuvich; Panos Deloukas; Cordelia Langford; Audrey Duncanson; Jorge R Oksenberg; Margaret A Pericak-Vance; Jonathan L Haines; Tomas Olsson; Jan Hillert; Adrian J Ivinson; Philip L De Jager; Leena Peltonen; Graeme J Stewart; David A Hafler; Stephen L Hauser; Gil McVean; Peter Donnelly; Alastair Compston
Journal:  Nature       Date:  2011-08-10       Impact factor: 49.962

10.  Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility.

Authors:  Matthew R Lincoln; Sreeram V Ramagopalan; Michael J Chao; Blanca M Herrera; Gabriele C Deluca; Sarah-Michelle Orton; David A Dyment; A Dessa Sadovnick; George C Ebers
Journal:  Proc Natl Acad Sci U S A       Date:  2009-04-20       Impact factor: 11.205
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  118 in total

Review 1.  Protective alleles and modifier variants in human health and disease.

Authors:  Andrew R Harper; Shalini Nayee; Eric J Topol
Journal:  Nat Rev Genet       Date:  2015-10-27       Impact factor: 53.242

Review 2.  Genetics of autoimmune diseases: perspectives from genome-wide association studies.

Authors:  Yuta Kochi
Journal:  Int Immunol       Date:  2016-02-08       Impact factor: 4.823

Review 3.  Lifestyle and Environmental Factors in Multiple Sclerosis.

Authors:  Lars Alfredsson; Tomas Olsson
Journal:  Cold Spring Harb Perspect Med       Date:  2019-04-01       Impact factor: 6.915

Review 4.  Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis.

Authors:  Tomas Olsson; Lisa F Barcellos; Lars Alfredsson
Journal:  Nat Rev Neurol       Date:  2016-12-09       Impact factor: 42.937

Review 5.  Autoimmune Subepidermal Bullous Diseases of the Skin and Mucosae: Clinical Features, Diagnosis, and Management.

Authors:  Kyle T Amber; Dedee F Murrell; Enno Schmidt; Pascal Joly; Luca Borradori
Journal:  Clin Rev Allergy Immunol       Date:  2018-02       Impact factor: 8.667

6.  Integrative Genetic and Epigenetic Analysis Uncovers Regulatory Mechanisms of Autoimmune Disease.

Authors:  Parisa Shooshtari; Hailiang Huang; Chris Cotsapas
Journal:  Am J Hum Genet       Date:  2017-07-06       Impact factor: 11.025

7.  Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis.

Authors:  Noriko Isobe; Anisha Keshavan; Pierre-Antoine Gourraud; Alyssa H Zhu; Esha Datta; Regina Schlaeger; Stacy J Caillier; Adam Santaniello; Antoine Lizée; Daniel S Himmelstein; Sergio E Baranzini; Jill Hollenbach; Bruce A C Cree; Stephen L Hauser; Jorge R Oksenberg; Roland G Henry
Journal:  JAMA Neurol       Date:  2016-07-01       Impact factor: 18.302

8.  Non-additive and epistatic effects of HLA polymorphisms contributing to risk of adult glioma.

Authors:  Chenan Zhang; Adam J de Smith; Ivan V Smirnov; John K Wiencke; Joseph L Wiemels; John S Witte; Kyle M Walsh
Journal:  J Neurooncol       Date:  2017-07-18       Impact factor: 4.130

9.  Absence of the tag polymorphism for the risk haplotype HLA-DR2 for multiple sclerosis in Wixárika subjects from Mexico.

Authors:  G V González-Enríquez; B M Torres-Mendoza; J Márquez-Pedroza; M A Macías-Islas; G G Ortiz; J A Cruz-Ramos
Journal:  Immunogenetics       Date:  2018-02-03       Impact factor: 2.846

10.  Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple sclerosis risk.

Authors:  Katarina Tengvall; Jesse Huang; Cecilia Hellström; Patrick Kammer; Martin Biström; Burcu Ayoglu; Izaura Lima Bomfim; Pernilla Stridh; Julia Butt; Nicole Brenner; Angelika Michel; Karin Lundberg; Leonid Padyukov; Ingrid E Lundberg; Elisabet Svenungsson; Ingemar Ernberg; Sigurgeir Olafsson; Alexander T Dilthey; Jan Hillert; Lars Alfredsson; Peter Sundström; Peter Nilsson; Tim Waterboer; Tomas Olsson; Ingrid Kockum
Journal:  Proc Natl Acad Sci U S A       Date:  2019-08-02       Impact factor: 11.205
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