Oculomotor functions of the flocculus and the vestibular nuclei after bilateral vestibular neurectomy.

Ito's hypothesis of an important role of the flocculus of the vestibulocerebellum in the immediate visual control of the VOR during visual-vestibular interaction has received substantial support. Nevertheless, several parts in this hypothesis are unclear, at least in primates. In normal monkey, vestibularly driven neurones in the vestibular nuclei do not carry signals which are adequate to account for the full range of eye movement responses during optokinetic tracking (OKN) and different situations of visual-vestibular interaction (especially VOR-suppression). Thus these neurones seem not to be located at the final stage where floccular "gaze-velocity" Purkinje cells (PCs) exert their control function on the three-neurone-reflex arc. The signals of these "central" vestibular neurones (if relevant for the oculomotor output) must further be processed. After bilateral vestibular neurectomy (BVN) only a small number of vestibular nuclei neurones were found with eye velocity sensitivities during smooth pursuit tracking (SP) and OKN in the range of those of floccular PCs (also after BVN), and with the appropriate polarity of modulation. Our difficulties in finding neurones in the vestibular nuclei which, according to their neurophysiological behaviour, could be main target cells of floccular PCs, either in normal or in BVN monkeys, are discussed.