Literature DB >> 26342722

Do statins prevent Alzheimer's disease? A narrative review.

Homayoun L Daneschvar1, Mark D Aronson2, Gerald W Smetana3.   

Abstract

Alzheimer's disease is the most common cause of dementia and occurs commonly in patients 65 and older. There is an urgent need to find an effective management that could help prevent or at least slow down the progress of this major public health problem. Cholesterol related pathways might play a role in the pathogenesis of Alzheimer's disease. Treatment with 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) has been suggested to promote the prevention of Alzheimer's disease. In this review, we discuss potential pathogenetic pathways for the development of Alzheimer's disease and review the evidence regarding the value of statins as a strategy to prevent or delay progression of Alzheimer's disease.
Copyright © 2015 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Alzheimer's disease; Dementia; Disease prevention; Statins

Mesh：

Substances：

Year:  2015        PMID： 26342722     DOI： 10.1016/j.ejim.2015.08.012

Source DB:  PubMed          Journal:  Eur J Intern Med        ISSN： 0953-6205            Impact factor:   4.487


  17 in total

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Review 2.  An overview on therapeutics attenuating amyloid β level in Alzheimer's disease: targeting neurotransmission, inflammation, oxidative stress and enhanced cholesterol levels.

Authors:  Xiaoling Zhou; Yifei Li; Xiaozhe Shi; Chun Ma
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Review 3.  The efficacy of statins in the treatment of Alzheimer's disease: a meta-analysis of randomized controlled trial.

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Journal:  Neurol Sci       Date:  2020-01-13       Impact factor: 3.307

Review 4.  Microglia Function in the Central Nervous System During Health and Neurodegeneration.

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Journal:  Annu Rev Immunol       Date:  2017-02-09       Impact factor: 28.527

Review 5.  The beneficial effects of HMG-CoA reductase inhibitors in the processes of neurodegeneration.

Authors:  Seyed Soheil Saeedi Saravi; Seyed Sobhan Saeedi Saravi; Alireza Arefidoust; Ahmad Reza Dehpour
Journal:  Metab Brain Dis       Date:  2017-06-03       Impact factor: 3.584

6.  Genetic susceptibility to cardiovascular disease and risk of dementia.

Authors:  I K Karlsson; A Ploner; C Song; M Gatz; N L Pedersen; S Hägg
Journal:  Transl Psychiatry       Date:  2017-05-30       Impact factor: 6.222

Review 7.  Nutrition and AGE-ing: Focusing on Alzheimer's Disease.

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Review 8.  Pharmacogenetics of Vascular Risk Factors in Alzheimer's Disease.

Authors:  Ramón Cacabelos; Arun Meyyazhagan; Juan C Carril; Pablo Cacabelos; Óscar Teijido
Journal:  J Pers Med       Date:  2018-01-03

Review 9.  Amyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta pores.

Authors:  Sage C Arbor; Mike LaFontaine; Medhane Cumbay
Journal:  Yale J Biol Med       Date:  2016-03-24

Review 10.  Overview and Current Status of Alzheimer's Disease in Bangladesh.

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Journal:  J Alzheimers Dis Rep       Date:  2017-07-01
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