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Literature DB >> 2634247

Carotid occlusion increases the release of endogenous GABA in the nucleus of the solitary tract.

Abstract

In anaesthetized cats, the nucleus of the solitary tract was bilaterally superfused through push-pull cannulae with artificial cerebrospinal fluid (CSF) and the effect of carotid occlusion on the release of endogenous GABA was investigated. Bilateral carotid occlusion led to a rise in blood pressure which was associated with a very pronounced increase in the release rate of GABA in the nucleus of the solitary tract. The results demonstrate the hypertensive function of GABA in the nucleus of the solitary tract and the importance of GABAergic neurons of this nucleus for the central cardiovascular control.

Entities: Chemical Disease Species

Mesh：

Substances：
gamma-Aminobutyric Acid

Year: 1989 PMID： 2634247 DOI： 10.1007/bf00169687

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

13 in total

1. Inhibition of GABA uptake in rat brain slices by nipecotic acid, various isoxazoles and related compounds.

Authors: P Krogsgaard-Larsen; G A Johnston
Journal: J Neurochem Date: 1975-12 Impact factor: 5.372

2. Effects of GABA analogues of restricted conformation on GABA transport in astrocytes and brain cortex slices and on GABA receptor binding.

Authors: A Schousboe; P Thorbek; L Hertz; P Krogsgaard-Larsen
Journal: J Neurochem Date: 1979-07 Impact factor: 5.372

3. Superfusion of the hypothalamus with gamma-aminobutyric acid. Effect on release of noradrenaline and blood pressure.

Authors: A Philippu; H Przuntek; W Roensberg
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1973 Impact factor: 3.000

4. Role of -aminobutyric acid (GABA) in the extrapyramidal motor system. 1. Regional distribution of GABA in rabbit, rat, guinea pig and baboon CNS.

Authors: Y Okada; C Nitsch-Hassler; J S Kim; I J Bak; R Hassler
Journal: Exp Brain Res Date: 1971-11-30 Impact factor: 1.972

5. Evidence for a neuromodulatory role of GABA at the first synapse of the baroreceptor reflex pathway. Effects of GABA derivatives injected into the NTS.

Authors: P Bousquet; J Feldman; R Bloch; J Schwartz
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1982-05 Impact factor: 3.000

6. In vivo release of endogenous GABA in the cat hypothalamus.

Authors: H Dietl; A Philippu
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1979-08 Impact factor: 3.000

7. Ultrastructural studies on catecholaminergic terminals and GABAergic neurons in nucleus tractus solitarius of the rat medulla oblongata.

Authors: B H Hwang; J Y Wu
Journal: Brain Res Date: 1984-06-04 Impact factor: 3.252

8. Intrinsic gamma-aminobutyric acid neurons in the nucleus of the solitary tract and the rostral ventrolateral medulla of the rat: an immunocytochemical and biochemical study.

Authors: M P Meeley; D A Ruggiero; T Ishitsuka; D J Reis
Journal: Neurosci Lett Date: 1985-07-04 Impact factor: 3.046

Carotid occlusion increases the release of endogenous GABA in the nucleus of the solitary tract.

1. Inhibition of GABA uptake in rat brain slices by nipecotic acid, various isoxazoles and related compounds.

2. Effects of GABA analogues of restricted conformation on GABA transport in astrocytes and brain cortex slices and on GABA receptor binding.

3. Superfusion of the hypothalamus with gamma-aminobutyric acid. Effect on release of noradrenaline and blood pressure.

4. Role of -aminobutyric acid (GABA) in the extrapyramidal motor system. 1. Regional distribution of GABA in rabbit, rat, guinea pig and baboon CNS.

5. Evidence for a neuromodulatory role of GABA at the first synapse of the baroreceptor reflex pathway. Effects of GABA derivatives injected into the NTS.

6. In vivo release of endogenous GABA in the cat hypothalamus.

7. Ultrastructural studies on catecholaminergic terminals and GABAergic neurons in nucleus tractus solitarius of the rat medulla oblongata.

8. Intrinsic gamma-aminobutyric acid neurons in the nucleus of the solitary tract and the rostral ventrolateral medulla of the rat: an immunocytochemical and biochemical study.

9. GABAergic mechanisms in nucleus tractus solitarius alter blood pressure and vasopressin release.

10. Immunohistochemistry of gamma-aminobutyric acid in the cat nucleus tractus solitarius.

1. Blood pressure changes modify the release rates of catecholamines in the intermediate nucleus of the solitary tract.

2. Effects of gamma-vinyl GABA (vigabatrin) on blood pressure and body weight of hypertensive and normotensive rats.

3. In vivo release patterns and cardiovascular properties of inhibitory and excitatory amino acids in the hypothalamus.