Jodi Shroba1, Jill Hanson2, Jay Portnoy2. 1. Children's Mercy Hospital, Kansas City, Missouri. Electronic address: jashroba@cmh.edu. 2. Children's Mercy Hospital, Kansas City, Missouri.
Abstract
BACKGROUND: Idiopathic angioedema is defined as localized swelling of the cutaneous and mucosal tissue that occurs in episodes without a clear etiology. It can be problematic to treat when the underlying pathophysiology is not well understood. OBJECTIVE: To identify successful treatments of idiopathic angioedema reported in the literature. METHODS: A literature search was performed using PubMed. Published case reports and articles discussing treatment of idiopathic angioedema were used in the formulation of this review. In addition, 2 case reports are provided. RESULTS: Although there are no approved treatments for idiopathic angioedema, several medications used for the treatment of hereditary angioedema, such as bradykinin receptor antagonists (icatibant), kallikrein inhibitors (ecallantide), and C1 inhibitors, were successful in 10 patients. Anti-IgE monoclonal antibody (omalizumab) proved successful in 5 patients. The most widely used and successful medication was tranexamic acid (154 patients). CONCLUSION: Despite an unknown etiology, this article highlights viable treatment options for idiopathic angioedema. More clinical trials and better markers identifying the cause of angioedema are needed.
BACKGROUND:Idiopathic angioedema is defined as localized swelling of the cutaneous and mucosal tissue that occurs in episodes without a clear etiology. It can be problematic to treat when the underlying pathophysiology is not well understood. OBJECTIVE: To identify successful treatments of idiopathic angioedema reported in the literature. METHODS: A literature search was performed using PubMed. Published case reports and articles discussing treatment of idiopathic angioedema were used in the formulation of this review. In addition, 2 case reports are provided. RESULTS: Although there are no approved treatments for idiopathic angioedema, several medications used for the treatment of hereditary angioedema, such as bradykinin receptor antagonists (icatibant), kallikrein inhibitors (ecallantide), and C1 inhibitors, were successful in 10 patients. Anti-IgE monoclonal antibody (omalizumab) proved successful in 5 patients. The most widely used and successful medication was tranexamic acid (154 patients). CONCLUSION: Despite an unknown etiology, this article highlights viable treatment options for idiopathic angioedema. More clinical trials and better markers identifying the cause of angioedema are needed.
Authors: Martin Christian Bucher; Tatjana Petkovic; Arthur Helbling; Urs Christian Steiner Journal: Clin Transl Allergy Date: 2017-08-31 Impact factor: 5.871
Authors: Enrico Brunetta; Dana Shiffer; Marco Folci; Maria I S Achenza; Francesca Puggioni; Enrico Heffler; Raffaello Furlan; Giorgio W Canonica Journal: Case Reports Immunol Date: 2018-07-22