Literature DB >> 26341615

Antinociceptive and anti-inflammatory effects of Caryocar coriaceum Wittm fruit pulp fixed ethyl acetate extract on zymosan-induced arthritis in rats.

Francisco Fábio Bezerra de Oliveira1, Joana Cláudia Bezerra de Araújo1, Anamaria Falcão Pereira1, Gerly Anne Castro Brito2, Delane Viana Gondim3, Ronaldo de Albuquerque Ribeiro1, Irwin Rose Alencar de Menezes4, Mariana Lima Vale5.   

Abstract

The ethyl acetate extract from the fruit pulp of Caryocar coriaceum Wittm (Caryocaraceae), popularly known as pequi, has wide applications in popular medicine. Preclinical tests have demonstrated the therapeutic properties of the oil. We investigated the antinociceptive and anti-inflammatory effects of Pequi C. coriaceum Wittm ethyl acetate extract (PCCO) on zymosan-induced arthritis in rat knee joint. The animals were pretreated with PCCO for 7 consecutive days or with a single dose. Paw elevation time (PET), leukocyte infiltration, myeloperoxidase activity (MPO) and cytokine levels were assessed 4h after zymosan injection. Synovial tissue was harvested for immunohistochemical analysis, edema and vascular permeability. We observed a significant decrease in PET with PCCO pretreatment. PCCO showed a significant reduction of leukocyte migration and a decrease in MPO. Decreases were observed in cytokine release in the synovial fluid and TNF-α and cyclooxygenase-1 immunostaining in synovial tissue. Edema was inhibited by treatment with all doses of PCCO. The data suggest that PCCO exerts antinociceptive and anti-inflammatory effects on arthritis in rats.
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Acid 11-eicosenoic (PubChem CID: 94159); Arthritis; Caryocar coriaceum Wittm; Heptadecenoico acid (PubChem CID: 5312435); Inflammation; Linoleic acid (PubChem CID: 5280450); Nociception; Oleic acid (PubChem CID: 445639); Palmitic acid (PubChem CID: 985); Palmitoleic acid (PubChem CID: 445638); Palmitoylethanolamide (PubChem CID: 4671); Stearic acid (PubChem CID: 5281); Zymosan

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Year:  2015        PMID： 26341615     DOI： 10.1016/j.jep.2015.08.017

Source DB:  PubMed          Journal:  J Ethnopharmacol        ISSN： 0378-8741            Impact factor:   4.360


  6 in total

1.  Thirty days after anterior cruciate ligament transection is sufficient to induce signs of knee osteoarthritis in rats: pain, functional impairment, and synovial inflammation.

Authors:  Germanna M Barbosa; Jonathan E Cunha; Thiago L Russo; Thiago M Cunha; Paula A T S Castro; Francisco F B Oliveira; Fernando Q Cunha; Fernando S Ramalho; Tania F Salvini
Journal:  Inflamm Res       Date:  2020-01-31       Impact factor: 4.575

2.  Immunomodulating action of the 3-phenylcoumarin derivative 6,7-dihydroxy-3-[3',4'-methylenedioxyphenyl]-coumarin in neutrophils from patients with rheumatoid arthritis and in rats with acute joint inflammation.

Authors:  Lucinéia Reuse Albiero; Micássio Fernandes de Andrade; Larissa Fávaro Marchi; Ana Paula Landi-Librandi; Andréa Silva Garcia de Figueiredo-Rinhel; Camila Andressa Carvalho; Luciana Mariko Kabeya; Renê Donizeti Ribeiro de Oliveira; Ana Elisa Caleiro Seixas Azzolini; Mônica Tallarico Pupo; Flávio da Silva Emery; Yara Maria Lucisano-Valim
Journal:  Inflamm Res       Date:  2019-11-30       Impact factor: 4.575

3.  Study on the Cytotoxic, Genotoxic and Clastogenic Potential of Attalea phalerata Mart. ex Spreng. Oil Pulp In Vitro and In Vivo Experimental Models.

Authors:  Fernando Freitas de Lima; Sara Emilia Lima Tolouei Menegati; Giseli Karenina Traesel; Flávio Henrique Souza de Araújo; Caroline Honaiser Lescano; Sara Moraes Peixoto; Felipe Ariel Mao Silva; Silvia Cristina Heredia Vieira; Maria do Carmo Vieira; Silvia Aparecida Oesterreich
Journal:  PLoS One       Date:  2016-10-20       Impact factor: 3.240

4.  Clinical-like cryotherapy improves footprint patterns and reduces synovial inflammation in a rat model of post-traumatic knee osteoarthritis.

Authors:  Germanna Medeiros Barbosa; Jonathan Emanuel Cunha; Thiago Mattar Cunha; Lizandra Botaro Martinho; Paula Aiello Tomé Souza Castro; Francisco Fábio Bezerra Oliveira; Fernando Queiróz Cunha; Fernando Silva Ramalho; Tania Fátima Salvini
Journal:  Sci Rep       Date:  2019-10-10       Impact factor: 4.379

5.  Pequi (Caryocar brasiliense Cambess)-Loaded Nanoemulsion, Orally Delivered, Modulates Inflammation in LPS-Induced Acute Lung Injury in Mice.

Authors:  Diego de Sá Coutinho; Jader Pires; Hyago Gomes; Adriana Raffin Pohlmann; Sílvia Stanisçuaski Guterres; Patrícia Machado Rodrigues E Silva; Marco Aurelio Martins; Stela Regina Ferrarini; Andressa Bernardi
Journal:  Pharmaceutics       Date:  2020-11-11       Impact factor: 6.321

Review 6.  Caryocar coriaceum Wittm. (Caryocaraceae): Botany, Ethnomedicinal Uses, Biological Activities, Phytochemistry, Extractivism and Conservation Needs.

Authors:  José Weverton Almeida-Bezerra; José Jailson Lima Bezerra; Viviane Bezerra da Silva; Henrique Douglas Melo Coutinho; José Galberto Martins da Costa; Natália Cruz-Martins; Christophe Hano; Saulo Almeida de Menezes; Maria Flaviana Bezerra Morais-Braga; Antonio Fernando Morais de Oliveira
Journal:  Plants (Basel)       Date:  2022-06-25
  6 in total

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