G D Barnes1, W Ageno2, J Ansell3, S Kaatz4. 1. Frankel Cardiovascular Center and Institute for Healthcare Policy and Innovation, University of Michigan Medical School, Ann Arbor, MI, USA. 2. Division of Internal Medicine, University of Insubria, Varese, Italy. 3. Department of Internal Medicine, Lenox Hill Hospital, New York City, NY, USA. 4. Hurley Medical Center, Michigan State University, Flint, MI, USA.