Literature DB >> 26340593

Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic.

Antoine Maruani1, Huguette Savoie, Francesca Bryden, Stephen Caddick, Ross Boyle, Vijay Chudasama.   

Abstract

Herein we present a significant step towards next-generation antibody-based photodynamic therapeutics. Site-selective modification of a clinically relevant monoclonal antibody, with a serum-stable linker bearing a strained alkyne, allows for the controlled Cu-free "click" assembly of an in vitro active antibody-based PDT agent using a water soluble azide porpyhrin.

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Year:  2015        PMID： 26340593     DOI： 10.1039/c5cc06985h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  13 in total

1.  Recent advances in the construction of antibody-drug conjugates.

Authors:  Vijay Chudasama; Antoine Maruani; Stephen Caddick
Journal:  Nat Chem       Date:  2016-01-04       Impact factor: 24.427

2.  Site-specific Bioconjugation and Convergent Click Chemistry Enhances Antibody-Chromophore Conjugate Binding Efficiency.

Authors:  Amissi Sadiki; Eric M Kercher; Haibin Lu; Ryan T Lang; Bryan Q Spring; Zhaohui Sunny Zhou
Journal:  Photochem Photobiol       Date:  2020-04-15       Impact factor: 3.421

3.  Supramolecular Assembly of Hybrid Pt(II) Porphyrin/Tomatine Analogues with Different Nanostructures and Cytotoxic Activities.

Authors:  Mayuko Fujitsuka; Daisuke Iohara; Sae Oumura; Misaki Matsushima; Mina Sakuragi; Makoto Anraku; Tsuyoshi Ikeda; Fumitoshi Hirayama; Keita Kuroiwa
Journal:  ACS Omega       Date:  2021-05-04

4.  Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy.

Authors:  R Dondi; E Yaghini; K M Tewari; L Wang; F Giuntini; M Loizidou; A J MacRobert; I M Eggleston
Journal:  Org Biomol Chem       Date:  2016-12-07       Impact factor: 3.876

5.  Forming next-generation antibody-nanoparticle conjugates through the oriented installation of non-engineered antibody fragments.

Authors:  Michelle K Greene; Daniel A Richards; João C F Nogueira; Katrina Campbell; Peter Smyth; Marcos Fernández; Christopher J Scott; Vijay Chudasama
Journal:  Chem Sci       Date:  2017-08-14       Impact factor: 9.825

6.  Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering.

Authors:  Maximillian T W Lee; Antoine Maruani; Daniel A Richards; James R Baker; Stephen Caddick; Vijay Chudasama
Journal:  Chem Sci       Date:  2016-11-28       Impact factor: 9.825

Review 7.  Site-Selective Disulfide Modification of Proteins: Expanding Diversity beyond the Proteome.

Authors:  Seah Ling Kuan; Tao Wang; Tanja Weil
Journal:  Chemistry       Date:  2016-10-25       Impact factor: 5.236

8.  Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones.

Authors:  Calise Bahou; Daniel A Richards; Antoine Maruani; Elizabeth A Love; Faiza Javaid; Stephen Caddick; James R Baker; Vijay Chudasama
Journal:  Org Biomol Chem       Date:  2018-02-21       Impact factor: 3.876

Review 9.  Methods to Design and Synthesize Antibody-Drug Conjugates (ADCs).

Authors:  Houzong Yao; Feng Jiang; Aiping Lu; Ge Zhang
Journal:  Int J Mol Sci       Date:  2016-02-02       Impact factor: 5.923

10.  Next-generation disulfide stapling: reduction and functional re-bridging all in one.

Authors:  Maximillian T W Lee; Antoine Maruani; James R Baker; Stephen Caddick; Vijay Chudasama
Journal:  Chem Sci       Date:  2015-09-15       Impact factor: 9.825
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