Literature DB >> 26340526

Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer.

Michael D Brooks1, Monika L Burness1, Max S Wicha2.   

Abstract

Cellular heterogeneity represents one of the greatest challenges in cancer therapeutics. In many malignancies, this heterogeneity is generated during tumor evolution through a combination of genetic alterations and epigenetic events that recapitulate normal developmental processes including stem cell self-renewal and differentiation. Many, if not most, tumors display similar hierarchal organization, at the apex of which are "stem-like cells" that drive tumor growth, mediate metastasis, and contribute to treatment resistance. Using breast cancer as a model, we discuss how an improved understanding of tumor cellular heterogeneity and plasticity may lead to development of more effective therapeutic strategies.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 26340526      PMCID： PMC4560840          DOI： 10.1016/j.stem.2015.08.014

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  123 in total

1.  Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer.

Authors:  José Baselga; Mario Campone; Martine Piccart; Howard A Burris; Hope S Rugo; Tarek Sahmoud; Shinzaburo Noguchi; Michael Gnant; Kathleen I Pritchard; Fabienne Lebrun; J Thaddeus Beck; Yoshinori Ito; Denise Yardley; Ines Deleu; Alejandra Perez; Thomas Bachelot; Luc Vittori; Zhiying Xu; Pabak Mukhopadhyay; David Lebwohl; Gabriel N Hortobagyi
Journal:  N Engl J Med       Date:  2011-12-07       Impact factor: 91.245

2.  Distinct stem cells contribute to mammary gland development and maintenance.

Authors:  Alexandra Van Keymeulen; Ana Sofia Rocha; Marielle Ousset; Benjamin Beck; Gaëlle Bouvencourt; Jason Rock; Neha Sharma; Sophie Dekoninck; Cédric Blanpain
Journal:  Nature       Date:  2011-10-09       Impact factor: 49.962

3.  Effects of the combination of RAD001 and docetaxel on breast cancer stem cells.

Authors:  Xiaobei Zhang; Sheng Zhang; Yan Liu; Jingjing Liu; Yi Ma; Yuanxi Zhu; Jin Zhang
Journal:  Eur J Cancer       Date:  2012-03-13       Impact factor: 9.162

4.  ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype.

Authors:  Simon Junankar; Laura A Baker; Daniel L Roden; Radhika Nair; Ben Elsworth; David Gallego-Ortega; Paul Lacaze; Aurélie Cazet; Iva Nikolic; Wee Siang Teo; Jessica Yang; Andrea McFarland; Kate Harvey; Matthew J Naylor; Sunil R Lakhani; Peter T Simpson; Ashwini Raghavendra; Jodi Saunus; Jason Madore; Warren Kaplan; Christopher Ormandy; Ewan K A Millar; Sandra O'Toole; Kyuson Yun; Alexander Swarbrick
Journal:  Nat Commun       Date:  2015-03-27       Impact factor: 14.919

5.  Trastuzumab emtansine for HER2-positive advanced breast cancer.

Authors:  Sunil Verma; David Miles; Luca Gianni; Ian E Krop; Manfred Welslau; José Baselga; Mark Pegram; Do-Youn Oh; Véronique Diéras; Ellie Guardino; Liang Fang; Michael W Lu; Steven Olsen; Kim Blackwell
Journal:  N Engl J Med       Date:  2012-10-01       Impact factor: 91.245

Review 6.  The Wnt/β-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancer.

Authors:  Taj D King; Mark J Suto; Yonghe Li
Journal:  J Cell Biochem       Date:  2012-01       Impact factor: 4.429

7.  HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: implications for efficacy of adjuvant trastuzumab.

Authors:  Suthinee Ithimakin; Kathleen C Day; Fayaz Malik; Qin Zen; Scott J Dawsey; Tom F Bersano-Begey; Ahmed A Quraishi; Kathleen Woods Ignatoski; Stephanie Daignault; April Davis; Christopher L Hall; Nallasivam Palanisamy; Amber N Heath; Nader Tawakkol; Tahra K Luther; Shawn G Clouthier; Whitney A Chadwick; Mark L Day; Celina G Kleer; Dafydd G Thomas; Daniel F Hayes; Hasan Korkaya; Max S Wicha
Journal:  Cancer Res       Date:  2013-02-26       Impact factor: 12.701

8.  Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas.

Authors:  Arnout G Schepers; Hugo J Snippert; Daniel E Stange; Maaike van den Born; Johan H van Es; Marc van de Wetering; Hans Clevers
Journal:  Science       Date:  2012-08-01       Impact factor: 47.728

9.  A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability.

Authors:  Peter Eirew; John Stingl; Afshin Raouf; Gulisa Turashvili; Samuel Aparicio; Joanne T Emerman; Connie J Eaves
Journal:  Nat Med       Date:  2008-11-23       Impact factor: 53.440

10.  A restricted cell population propagates glioblastoma growth after chemotherapy.

Authors:  Jian Chen; Yanjiao Li; Tzong-Shiue Yu; Renée M McKay; Dennis K Burns; Steven G Kernie; Luis F Parada
Journal:  Nature       Date:  2012-08-23       Impact factor: 49.962
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  154 in total

1.  Murine melanoma cells incomplete reprogramming using non-viral vector.

Authors:  D A D Câmara; A S Porcacchia; A S Costa; R A Azevedo; I Kerkis
Journal:  Cell Prolif       Date:  2017-06-15       Impact factor: 6.831

2.  Oncofetal Epigenetic Bivalency in Breast Cancer Cells: H3K4 and H3K27 Tri-Methylation as a Biomarker for Phenotypic Plasticity.

Authors:  Terri L Messier; Joseph R Boyd; Jonathan A R Gordon; Janet L Stein; Jane B Lian; Gary S Stein
Journal:  J Cell Physiol       Date:  2016-03-10       Impact factor: 6.384

3.  HER2-Driven Breast Tumorigenesis Relies upon Interactions of the Estrogen Receptor with Coactivator MED1.

Authors:  Yongguang Yang; Marissa Leonard; Yijuan Zhang; Dan Zhao; Charif Mahmoud; Shugufta Khan; Jiang Wang; Elyse E Lower; Xiaoting Zhang
Journal:  Cancer Res       Date:  2017-11-29       Impact factor: 12.701

Review 4.  The changing paradigm of tumour response to irradiation.

Authors:  Richard P Hill
Journal:  Br J Radiol       Date:  2016-08-02       Impact factor: 3.039

5.  Metabolic history impacts mammary tumor epithelial hierarchy and early drug response in mice.

Authors:  Maria Theresa E Montales; Stepan B Melnyk; Shi J Liu; Frank A Simmen; Y Lucy Liu; Rosalia C M Simmen
Journal:  Endocr Relat Cancer       Date:  2016-07-08       Impact factor: 5.678

Review 6.  Starvation and Pseudo-Starvation as Drivers of Cancer Metastasis through Translation Reprogramming.

Authors:  Custodia García-Jiménez; Colin R Goding
Journal:  Cell Metab       Date:  2018-12-20       Impact factor: 27.287

Review 7.  Breast Cancer: Multiple Subtypes within a Tumor?

Authors:  Syn Kok Yeo; Jun-Lin Guan
Journal:  Trends Cancer       Date:  2017-10-24

Review 8.  Hypoxia-inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype.

Authors:  Gregg L Semenza
Journal:  EMBO J       Date:  2016-12-22       Impact factor: 11.598

9.  Autophagy Differentially Regulates Distinct Breast Cancer Stem-like Cells in Murine Models via EGFR/Stat3 and Tgfβ/Smad Signaling.

Authors:  Syn Kok Yeo; Jian Wen; Song Chen; Jun-Lin Guan
Journal:  Cancer Res       Date:  2016-04-13       Impact factor: 12.701

10.  Targeting BMI1+ Cancer Stem Cells Overcomes Chemoresistance and Inhibits Metastases in Squamous Cell Carcinoma.

Authors:  Demeng Chen; Mansi Wu; Yang Li; Insoon Chang; Quan Yuan; Mari Ekimyan-Salvo; Peng Deng; Bo Yu; Yongxin Yu; Jiaqiang Dong; John M Szymanski; Sivakumar Ramadoss; Jiong Li; Cun-Yu Wang
Journal:  Cell Stem Cell       Date:  2017-03-09       Impact factor: 24.633
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