Samantha Slotnick1,2, Yin Ding3, Sofya Glazman4, Mary Durbin5, Shahnaz Miri6, Ivan Selesnick3, Jerome Sherman2, Ivan Bodis-Wollner4,7,8. 1. Scarsdale, New York, USA. 2. SUNY College of Optometry, New York, New York, USA. 3. New York University, School of Engineering, Brooklyn, New York, USA. 4. SUNY Downstate Medical Center, Department of Neurology, Brooklyn, New York, USA. 5. Carl Zeiss-Meditec, Inc, Dublin, California, USA. 6. Medstar Union Memorial Hospital, Department of Medicine, Baltimore, Maryland, USA. 7. SUNY Downstate Medical Center, Department of Ophthalmology, Brooklyn, New York, USA. 8. SUNY Eye Institute, Syracuse, New York, USA.
Abstract
BACKGROUND: Optical coherence tomography offers a potential biomarker tool in Parkinson's disease (PD). A mathematical model quantifying symmetry, breadth, and depth of the fovea was applied. METHODS: Nintey-six subjects (72 PD and 24 healthy controls) were included in the study. Macular scans of each eye were obtained on two different optical coherence tomography devices: Cirrus and RTVue. RESULTS: The variables corresponding to the cardinal gradients of the fovea were the most sensitive indicators of PD for both devices. Principal component analysis distinguished 65% of PD patients from controls on Cirrus, 57% on RTVue. CONCLUSION: Parkinson's disease shallows the superior/inferior and to a lesser degree nasal-temporal foveal slope. The symmetry, breadth, and depth model fits optical coherence tomography data derived from two different devices, and it is proposed as a diagnostic tool in PD.
BACKGROUND: Optical coherence tomography offers a potential biomarker tool in Parkinson's disease (PD). A mathematical model quantifying symmetry, breadth, and depth of the fovea was applied. METHODS: Nintey-six subjects (72 PD and 24 healthy controls) were included in the study. Macular scans of each eye were obtained on two different optical coherence tomography devices: Cirrus and RTVue. RESULTS: The variables corresponding to the cardinal gradients of the fovea were the most sensitive indicators of PD for both devices. Principal component analysis distinguished 65% of PDpatients from controls on Cirrus, 57% on RTVue. CONCLUSION:Parkinson's disease shallows the superior/inferior and to a lesser degree nasal-temporal foveal slope. The symmetry, breadth, and depth model fits optical coherence tomography data derived from two different devices, and it is proposed as a diagnostic tool in PD.
Authors: Isabel Ortuño-Lizarán; Thomas G Beach; Geidy E Serrano; Douglas G Walker; Charles H Adler; Nicolás Cuenca Journal: Mov Disord Date: 2018-05-08 Impact factor: 10.338
Authors: Atsuro Uchida; Jagan A Pillai; Robert Bermel; Aaron Bonner-Jackson; Alexander Rae-Grant; Hubert Fernandez; James Bena; Stephen E Jones; James B Leverenz; Sunil K Srivastava; Justis P Ehlers Journal: Invest Ophthalmol Vis Sci Date: 2018-06-01 Impact factor: 4.799