Bo Wang1, Xiaoling Wang1, Yinying Zou1. 1. Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou, China.
Abstract
PURPOSE: To investigate the association between hormone receptors and HER-2/neu in different age groups of women with breast cancers. METHODS: A total of 1036 women with breast cancers were recruited. All the patients were divided into nine groups. The expression of hormone receptors and HER-2/neu was studied by IHC, while FISH test was used to determine HER-2/neu status in cases scored IHC 2+. The association between hormone receptors and HER-2/neu in different age groups was evaluated using the χ(2) test. Multivariate analysis was used to find out the independent factors predicting HER-2/neu amplification. Significant findings: The expression of ER and PR was inversely correlated with HER-2/neu status in women aged >40 years. By multivariate analysis, as far as the overall groups were concerned, PR, lymph node status and tumor grade were independently associated with HER-2/neu; Considering the younger age group (≤ 40), the only predictor for HER-2/neu was the tumor grade; Considering the older age group (>40), tumor grade, PR status, tumor size and lymph node status were associated with HER-2/neu overexpression. CONCLUSIONS: Our data suggest that the association between ER, PR and HER-2/neu is age-related. The negative relationship is only applied for women aged >40 years.
PURPOSE: To investigate the association between hormone receptors and HER-2/neu in different age groups of women with breast cancers. METHODS: A total of 1036 women with breast cancers were recruited. All the patients were divided into nine groups. The expression of hormone receptors and HER-2/neu was studied by IHC, while FISH test was used to determine HER-2/neu status in cases scored IHC 2+. The association between hormone receptors and HER-2/neu in different age groups was evaluated using the χ(2) test. Multivariate analysis was used to find out the independent factors predicting HER-2/neu amplification. Significant findings: The expression of ER and PR was inversely correlated with HER-2/neu status in women aged >40 years. By multivariate analysis, as far as the overall groups were concerned, PR, lymph node status and tumor grade were independently associated with HER-2/neu; Considering the younger age group (≤ 40), the only predictor for HER-2/neu was the tumor grade; Considering the older age group (>40), tumor grade, PR status, tumor size and lymph node status were associated with HER-2/neu overexpression. CONCLUSIONS: Our data suggest that the association between ER, PR and HER-2/neu is age-related. The negative relationship is only applied for women aged >40 years.
Authors: R Zeillinger; F Kury; K Czerwenka; E Kubista; G Sliutz; W Knogler; J Huber; C Zielinski; G Reiner; R Jakesz Journal: Oncogene Date: 1989-01 Impact factor: 9.867
Authors: H J Huang; P Neven; M Drijkoningen; R Paridaens; H Wildiers; E Van Limbergen; P Berteloot; F Amant; I Vergote; M R Christiaens Journal: J Clin Pathol Date: 2005-06 Impact factor: 3.411
Authors: Han Zhang; Guoping Ren; Xiaoling Wang; Jing Zhao; Hongtian Yao; Yanfeng Bai; Wang Bo Journal: Breast Cancer Res Treat Date: 2012-06-08 Impact factor: 4.872