Literature DB >> 26339348

Neural stem cell transplantation promotes behavioral recovery in a photothrombosis stroke model.

Junning Ma1, Junwei Gao1, Boru Hou1, Jixing Liu2, Sihua Chen2, Guizhong Yan2, Haijun Ren1.   

Abstract

Stem cell-based therapy provides a promising approach for treat stroke. Neural stem cells isolated from mice hippocampus possessing the capacity of differentiate into neurons and astrocytes both in vitro and vivo. Here, we investigated the capability of neural stem cell transplantation in photothrombosis stroke model. Nissl staining revealed that the cortical infarct significantly decreased by 16.32% (Vehicle: 27.93le: an mm(3), n=6, NSC: 23.37le: ai mm(3), n=6, P<0.05) in the NSC group compared with the vehicle. More over transplantation of neural stem cells significantly (P<0.01) improved neurological performance compared with vehicle. These results indicate that transplantation of neural stem cell is an effective therapy in ischemic stroke.

Entities:  

Keywords:  Neural stem cell; functional recovery; ischemic stroke; photothrombotic model; transplantation

Mesh：

Year:  2015        PMID： 26339348      PMCID： PMC4555676     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  43 in total

1.  Cell number and timing of transplantation determine survival of human neural stem cell grafts in stroke-damaged rat brain.

Authors:  Vladimer Darsalia; Susan J Allison; Carlo Cusulin; Emanuela Monni; Daniela Kuzdas; Therése Kallur; Olle Lindvall; Zaal Kokaia
Journal:  J Cereb Blood Flow Metab       Date:  2010-06-09       Impact factor: 6.200

2.  Generating and measuring photochemical changes inside the brain using optical fibers: exploring stroke.

Authors:  Georgios Tsiminis; Thomas S Klarić; Erik P Schartner; Stephen C Warren-Smith; Martin D Lewis; Simon A Koblar; Tanya M Monro
Journal:  Biomed Opt Express       Date:  2014-10-16       Impact factor: 3.732

3.  Grafted human neural stem cells enhance several steps of endogenous neurogenesis and improve behavioral recovery after middle cerebral artery occlusion in rats.

Authors:  Yutaka Mine; Jemal Tatarishvili; Koichi Oki; Emanuela Monni; Zaal Kokaia; Olle Lindvall
Journal:  Neurobiol Dis       Date:  2012-12-28       Impact factor: 5.996

4.  Interleukin 6-preconditioned neural stem cells reduce ischaemic injury in stroke mice.

Authors:  Hiroyuki Sakata; Purnima Narasimhan; Kuniyasu Niizuma; Carolina M Maier; Takuma Wakai; Pak H Chan
Journal:  Brain       Date:  2012-11       Impact factor: 13.501

5.  Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable.

Authors:  Marc Fisher; Gregory W Albers; Geoffrey A Donnan; Anthony J Furlan; James C Grotta; Chelsea S Kidwell; Ralph L Sacco; Lawrence R Wechsler
Journal:  Stroke       Date:  2005-07-14       Impact factor: 7.914

6.  Neural stem cell transplantation benefits a monogenic neurometabolic disorder during the symptomatic phase of disease.

Authors:  Mylvaganam Jeyakumar; Jean-Pyo Lee; Nicola R Sibson; John P Lowe; Daniel J Stuckey; Katie Tester; Gerald Fu; Robin Newlin; David A Smith; Evan Y Snyder; Frances M Platt
Journal:  Stem Cells       Date:  2009-09       Impact factor: 6.277

Review 7.  Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century.

Authors:  Valery L Feigin; Carlene M M Lawes; Derrick A Bennett; Craig S Anderson
Journal:  Lancet Neurol       Date:  2003-01       Impact factor: 44.182

Review 8.  Identifying patient populations at high risk for stroke.

Authors:  R L Sacco
Journal:  Neurology       Date:  1998-09       Impact factor: 9.910

9.  Transplanted bone marrow stromal cells migrate, differentiate and improve motor function in rats with experimentally induced cerebral stroke.

Authors:  Jeng-Rung Chen; Guang-Yan Cheng; Ching-Chung Sheu; Guo-Fang Tseng; Tsyr-Jiuan Wang; Yong-San Huang
Journal:  J Anat       Date:  2008-07-18       Impact factor: 2.610

Review 10.  Stem cell-based treatments against stroke: observations from human proof-of-concept studies and considerations regarding clinical applicability.

Authors:  Thorsten R Doeppner; Dirk M Hermann
Journal:  Front Cell Neurosci       Date:  2014-10-29       Impact factor: 5.505
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  4 in total

1.  Fasudil Enhances Therapeutic Efficacy of Neural Stem Cells in the Mouse Model of MPTP-Induced Parkinson's Disease.

Authors:  Yan-Hua Li; Jing-Wen Yu; Jian-Yin Xi; Wen-Bo Yu; Jian-Chun Liu; Qing Wang; Li-Juan Song; Ling Feng; Ya-Ping Yan; Guang-Xian Zhang; Bao-Guo Xiao; Cun-Gen Ma
Journal:  Mol Neurobiol       Date:  2016-09-02       Impact factor: 5.590

Review 2.  Stem Cell-Based Therapy for Experimental Ischemic Stroke: A Preclinical Systematic Review.

Authors:  Xi-Le Zhang; Xiao-Guang Zhang; Yan-Ran Huang; Yan-Yan Zheng; Peng-Jie Ying; Xiao-Jie Zhang; Xiao Lu; Yi-Jing Wang; Guo-Qing Zheng
Journal:  Front Cell Neurosci       Date:  2021-04-14       Impact factor: 5.505

3.  Radial Extracorporeal Shock Wave Therapy Enhances the Proliferation and Differentiation of Neural Stem Cells by Notch, PI3K/AKT, and Wnt/β-catenin Signaling.

Authors:  Jing Zhang; Nan Kang; Xiaotong Yu; Yuewen Ma; Xining Pang
Journal:  Sci Rep       Date:  2017-11-10       Impact factor: 4.379

4.  Effect of human mesenchymal stem cell transplantation on cerebral ischemic volume-controlled photothrombotic mouse model.

Authors:  Yun-Kyong Choi; Enerelt Urnukhsaikhan; Hee-Hoon Yoon; Young-Kwon Seo; Jung-Keug Park
Journal:  Biotechnol J       Date:  2016-10-11       Impact factor: 4.677
  4 in total

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