| Literature DB >> 26338363 |
Adam Huczyński1, Greta Klejborowska2, Michał Antoszczak2, Ewa Maj3, Joanna Wietrzyk3.
Abstract
New tertiary amide derivatives of polyether ionophore Monensin A (MON) were synthesised and their anti-proliferative activity against cancer cell lines was studied. Very high activity (IC50=0.09 μM) and selectivity (SI=232) of MON against human biphenotypic myelomonocytic leukemia cell line (MV4-11) was demonstrated. The MON derivatives obtained exhibit interesting anti-proliferative activity, high selectivity index and also are able to break the drug-resistance of cancer cell line.Entities:
Keywords: Anti-proliferative activity; Natural products; Polyether ionophores; Selectivity; Tertiary amides
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Year: 2015 PMID： 26338363 DOI： 10.1016/j.bmcl.2015.08.067
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823