Francesca Montarolo1, Simona Perga2, Serena Martire2, Antonio Bertolotto2. 1. AOU San Luigi Gonzaga, Neurobiology Unit, Neurologia 2, CReSM (Regional Referring Center of Multiple Sclerosis) and Neuroscience Institute Cavalieri Ottolenghi (NICO), Regione Gonzole, 10, 10043, Orbassano, TO, Italy. francesca.montarolo@unito.it. 2. AOU San Luigi Gonzaga, Neurobiology Unit, Neurologia 2, CReSM (Regional Referring Center of Multiple Sclerosis) and Neuroscience Institute Cavalieri Ottolenghi (NICO), Regione Gonzole, 10, 10043, Orbassano, TO, Italy.
Abstract
OBJECTIVE: Nurr1 plays anti-inflammatory functions in astrocytes/microglia. Gene expression analysis reveals Nurr1 down-regulation in PBMCs of MS patients that negatively correlates with disease aggressiveness. This study assesses the consequences of Nurr1 reduction in a MS model represented by EAE. METHODS: EAE was induced in heterozygous Nurr1 knockout mice. Clinical course was evaluated during pre-symptomatic, acute, and chronic phases. Neurohistopathological state was analyzed in spinal cord. RESULTS AND CONCLUSIONS: Nurr1 defect induces early EAE onset and increases inflammatory infiltrates in spinal cord suggesting a Nurr1 role in the early phase of EAE.
OBJECTIVE:Nurr1 plays anti-inflammatory functions in astrocytes/microglia. Gene expression analysis reveals Nurr1 down-regulation in PBMCs of MSpatients that negatively correlates with disease aggressiveness. This study assesses the consequences of Nurr1 reduction in a MS model represented by EAE. METHODS: EAE was induced in heterozygous Nurr1 knockout mice. Clinical course was evaluated during pre-symptomatic, acute, and chronic phases. Neurohistopathological state was analyzed in spinal cord. RESULTS AND CONCLUSIONS:Nurr1 defect induces early EAE onset and increases inflammatory infiltrates in spinal cord suggesting a Nurr1 role in the early phase of EAE.
Authors: O Saucedo-Cardenas; J D Quintana-Hau; W D Le; M P Smidt; J J Cox; F De Mayo; J P Burbach; O M Conneely Journal: Proc Natl Acad Sci U S A Date: 1998-03-31 Impact factor: 11.205
Authors: Francesca Gilli; Raija L P Lindberg; Paola Valentino; Fabiana Marnetto; Simona Malucchi; Arianna Sala; Marco Capobianco; Alessia di Sapio; Francesca Sperli; Ludwig Kappos; Raffaele A Calogero; Antonio Bertolotto Journal: PLoS One Date: 2010-01-29 Impact factor: 3.240
Authors: H Takahashi; H Tsuboi; H Asashima; T Hirota; Y Kondo; M Moriyama; I Matsumoto; S Nakamura; T Sumida Journal: Clin Exp Immunol Date: 2017-07-21 Impact factor: 4.330