| Literature DB >> 26337155 |
Hisayuki Komaki1, Natsuko Ichikawa2, Akira Hosoyama2, Nobuyuki Fujita2, Yasuhiro Igarashi3.
Abstract
We report the draft genome sequence of marine-derived Streptomyces sp. TP-A0882, a producer of buryrolactol, an antifungal γ-lactone-containing polyketide. The genome harbored at least three type I polyketide synthase (PKS), three type II PKS, four nonribosomal peptide synthetase (NRPS) and two hybrid PKS/NRPS gene clusters. Annotation of gene functions enabled us to identify the type I PKS gene cluster for butyrolactol biosynthesis and propose a plausible biosynthetic pathway for this unique polyketide. © FEMS 2015. All rights reserved.Entities:
Keywords: Actinomycete; antibiotic; biosynthesis; genome mining; thiazostatin
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Year: 2015 PMID： 26337155 DOI： 10.1093/femsle/fnv155
Source DB: PubMed Journal: FEMS Microbiol Lett ISSN： 0378-1097 Impact factor: 2.742