| Literature DB >> 26337019 |
Suresh Paudel1, Yongkai Cao1, Shuohan Guo1, Byeongkwan An2, Kyeong-Man Kim3, Seung Hoon Cheon4.
Abstract
A series of 4-benzylpiperidine carboxamides were designed and synthesized, and tested for their dual (serotonin and norepinephrine) reuptake inhibition. The synthesis of 4-benzylpiperidine carboxamides involved two main steps: amidation and substitution. Derivatives with 3 carbon linker displayed better activity than with 2 carbon linker. 4-Biphenyl- and 2-naphthyl-substituted derivatives 7e and 7j showed greater dual reuptake inhibition than standard drug venlafaxine HCl.Entities:
Keywords: 4-Benzylpiperidine carboxamide; Norepinephrine reuptake inhibitor; Serotonin reuptake inhibitor
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Year: 2015 PMID： 26337019 DOI： 10.1016/j.bmc.2015.08.022
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641