Literature DB >> 26336535

Oral direct renin inhibitor aliskiren reduces in vivo oxidative stress and serum matrix metalloproteinase-2 levels in patients with permanent atrial fibrillation.

Yoshizumi Takei1, Minoru Ichikawa1, Yoshiyuki Kijima1.   

Abstract

We aimed to determine the effects of the oral direct renin inhibitor aliskiren on in vivo oxidative stress in atrial fibrillation (AF) patients. In this study, 150 mg oral direct renin inhibitor aliskiren was administered once daily to 12 permanent AF patients. Aliskiren significantly reduced urinary excretion of the oxidative stress biomarker 8-iso-prostglandin F2α and serum levels of matrix metalloproteinase-2(MMP-2). We concluded that aliskiren reduces in vivo oxidative stress and serum MMP-2 levels in patients with permanent AF.

Entities:  

Keywords:  Atrial fibrillation; Free radicals; Matrix metalloproteinase

Year:  2014        PMID： 26336535      PMCID： PMC4550121          DOI： 10.1016/j.joa.2014.07.002

Source DB:  PubMed          Journal:  J Arrhythm        ISSN： 1880-4276


  8 in total

1.  Additive renoprotective effects of aliskiren on angiotensin receptor blocker and calcium channel blocker treatments for type 2 diabetic patients with albuminuria.

Authors:  Masanori Abe; Noriaki Maruyama; Hiroko Suzuki; Yuki Fujii; Midori Ito; Yoshinori Yoshida; Kazuyoshi Okada; Masayoshi Soma
Journal:  Hypertens Res       Date:  2012-05-17       Impact factor: 3.872

2.  Reactive oxidative metabolites are associated with atrial conduction disturbance in patients with atrial fibrillation.

Authors:  Masayuki Shimano; Rei Shibata; Yasuya Inden; Naoki Yoshida; Tomohiro Uchikawa; Yukiomi Tsuji; Toyoaki Murohara
Journal:  Heart Rhythm       Date:  2009-03-11       Impact factor: 6.343

3.  Impact of biomarkers of inflammation and extracellular matrix turnover on the outcome of atrial fibrillation ablation: importance of matrix metalloproteinase-2 as a predictor of atrial fibrillation recurrence.

Authors:  Yasuo Okumura; Ichiro Watanabe; Toshiko Nakai; Kimie Ohkubo; Tatsuya Kofune; Masayoshi Kofune; Koichi Nagashima; Hiroaki Mano; Kazumasa Sonoda; Yuji Kasamaki; Atsushi Hirayama
Journal:  J Cardiovasc Electrophysiol       Date:  2011-04-13

Review 4.  Regulation of matrix metalloproteinases by cytokines and reactive oxygen/nitrogen species in the myocardium.

Authors:  Deborah A Siwik; Wilson S Colucci
Journal:  Heart Fail Rev       Date:  2004-01       Impact factor: 4.214

5.  Oxidative stress markers are associated with persistent atrial fibrillation.

Authors:  Robert B Neuman; Heather L Bloom; Irfan Shukrullah; Lyndsey A Darrow; David Kleinbaum; Dean P Jones; Samuel C Dudley
Journal:  Clin Chem       Date:  2007-06-28       Impact factor: 8.327

6.  Transient enhancement of oxidant stress and collagen turnover in patients with acute worsening of congestive heart failure.

Authors:  Megumi Kunishige; Yoshiyuki Kijima; Taku Sakai; Osamu Akutagawa; Akiko Matsuo; Akira Nishibe; Yusuke Nakagawa; Takeshi Hata
Journal:  Circ J       Date:  2007-12       Impact factor: 2.993

7.  Extracellular matrix alterations in patients with paroxysmal and persistent atrial fibrillation: biochemical assessment of collagen type-I turnover.

Authors:  Eleftherios M Kallergis; Emmanuel G Manios; Emmanuel M Kanoupakis; Hercules E Mavrakis; Dimitris A Arfanakis; Niki E Maliaraki; Chrisovalantis E Lathourakis; Gregory I Chlouverakis; Panos E Vardas
Journal:  J Am Coll Cardiol       Date:  2008-07-15       Impact factor: 24.094

8.  Atrial extracellular matrix remodelling in patients with atrial fibrillation.

Authors:  V Polyakova; S Miyagawa; Z Szalay; J Risteli; S Kostin
Journal:  J Cell Mol Med       Date:  2008-01-10       Impact factor: 5.310
  8 in total

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