Literature DB >> 26335963

In Situ Generated Fluorinated Iminium Salts for Difluoromethylation and Difluoroacetylation.

Etienne Schmitt1, Baptiste Rugeri1, Armen Panossian1, Jean-Pierre Vors2, Sergii Pazenok3, Frédéric R Leroux1.   

Abstract

The use of TFEDMA, a fluoroalkyl amino reagent, for the difluoromethylation and difluoroacylation of arenes, heteroarenes, and C-H acidic compounds is reported. This approach allows for an efficient access to difluoromethylated products of high added value in good to excellent yields and with scale-up possibilities.

Entities:  

Year:  2015        PMID： 26335963     DOI： 10.1021/acs.orglett.5b02184

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  5 in total

1.  Regioselective Synthesis of Functionalized 3- or 5-Fluoroalkyl Isoxazoles and Pyrazoles from Fluoroalkyl Ynones and Binucleophiles.

Authors:  Bohdan A Chalyk; Andrii Khutorianskyi; Andrii Lysenko; Yulia Fil; Yuliya O Kuchkovska; Konstantin S Gavrilenko; Iulia Bakanovych; Yurii S Moroz; Alina O Gorlova; Oleksandr O Grygorenko
Journal:  J Org Chem       Date:  2019-11-08       Impact factor: 4.354

2.  Formation of synthetically relevant CF3-substituted phenonium ions in superacid media.

Authors:  Anthony J Fernandes; Bastien Michelet; Armen Panossian; Agnès Martin-Mingot; Frédéric R Leroux; Sébastien Thibaudeau
Journal:  RSC Adv       Date:  2021-07-26       Impact factor: 3.361

3.  Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides.

Authors:  Changhui Lu; Yang Gu; Jiang Wu; Yucheng Gu; Qilong Shen
Journal:  Chem Sci       Date:  2017-04-24       Impact factor: 9.825

Review 4.  Fluoroalkyl Amino Reagents (FARs): A General Approach towards the Synthesis of Heterocyclic Compounds Bearing Emergent Fluorinated Substituents.

Authors:  Bruno Commare; Etienne Schmitt; Fallia Aribi; Armen Panossian; Jean-Pierre Vors; Sergiy Pazenok; Frédéric R Leroux
Journal:  Molecules       Date:  2017-06-12       Impact factor: 4.411

5.  Synthesis of Fluorinated Amide Derivatives via a Radical N-Perfluoroalkylation-Defluorination Pathway.

Authors:  Zhiyao Zheng; Angela van der Werf; Marie Deliaval; Nicklas Selander
Journal:  Org Lett       Date:  2020-03-25       Impact factor: 6.005
  5 in total

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