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Literature DB >> 26335653

The Influence of Bariatric Surgery on Serum Bile Acids in Humans and Potential Metabolic and Hormonal Implications: a Systematic Review.

Abigail J Cole¹, Levi M Teigen², Cyrus Jahansouz³, Carrie P Earthman⁴, Shalamar D Sibley⁵.

Abstract

Recent research suggests a mechanistic role for bile acids (BA) in the metabolic improvement following bariatric surgery. It is believed that the hormonal and metabolic effects associated with changes in systemic BAs may be related to the farnesoid X receptor (FXR) and a G-protein coupled receptor (TGR5). This systematic review examines changes in systemic BAs following bariatric procedures. Studies were included if they reported the measurement of systemic BAs in humans at at least one time point after bariatric surgery. Eleven papers were identified that met the inclusion criteria. Seven studies reported the effect of Roux-en-Y gastric bypass (RYGB) on fasting BAs. The majority (6/7) reported that fasting BAs increased after RYGB. Data regarding fasting BAs after vertical sleeve gastrectomy (VSG) and laparoscopic gastric banding (LAGB) are inconsistent. Data regarding post-prandial BA changes after RYGB, VSG, and LAGB are also inconsistent. More research is needed to investigate the connection between BAs and the metabolic improvement seen after bariatric surgery.

Entities: Chemical Gene Species

Keywords: Bariatric surgery; Bile acids; FXR; Gastric bypass; Metabolism; Obesity; RYGB; TGR5; Vertical sleeve gastrectomy

Mesh：

Substances：
Bile Acids and Salts

Year: 2015 PMID： 26335653 DOI： 10.1007/s13679-015-0171-x

Source DB: PubMed Journal: Curr Obes Rep ISSN： 2162-4968

52 in total

1. Activation of the farnesoid X receptor induces hepatic expression and secretion of fibroblast growth factor 21.

Authors: Holly A Cyphert; Xuemei Ge; Alison B Kohan; Lisa M Salati; Yanqiao Zhang; F Bradley Hillgartner
Journal: J Biol Chem Date: 2012-06-01 Impact factor: 5.157

Review 2. The physiology underlying Roux-en-Y gastric bypass: a status report.

Authors: Thomas A Lutz; Marco Bueter
Journal: Am J Physiol Regul Integr Comp Physiol Date: 2014-09-24 Impact factor: 3.619

3. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR.

Authors: H Wang; J Chen; K Hollister; L C Sowers; B M Forman
Journal: Mol Cell Date: 1999-05 Impact factor: 17.970

4. Identification of a nuclear receptor for bile acids.

Authors: M Makishima; A Y Okamoto; J J Repa; H Tu; R M Learned; A Luk; M V Hull; K D Lustig; D J Mangelsdorf; B Shan
Journal: Science Date: 1999-05-21 Impact factor: 47.728

5. Enhanced fasting and post-prandial plasma bile acid responses after Roux-en-Y gastric bypass surgery.

Authors: Malin Werling; Royce P Vincent; Gemma F Cross; Hanns-Ulrich Marschall; Lars Fändriks; Hans Lönroth; David R Taylor; Jamshid Alaghband-Zadeh; Torsten Olbers; Carel W Le Roux
Journal: Scand J Gastroenterol Date: 2013-09-18 Impact factor: 2.423

6. Steady-state kinetics of serum bile acids in healthy human subjects: single and dual isotope techniques using stable isotopes and mass spectrometry.

Authors: G T Everson
Journal: J Lipid Res Date: 1987-03 Impact factor: 5.922

7. TGR5-mediated bile acid sensing controls glucose homeostasis.

Authors: Charles Thomas; Antimo Gioiello; Lilia Noriega; Axelle Strehle; Julien Oury; Giovanni Rizzo; Antonio Macchiarulo; Hiroyasu Yamamoto; Chikage Mataki; Mark Pruzanski; Roberto Pellicciari; Johan Auwerx; Kristina Schoonjans
Journal: Cell Metab Date: 2009-09 Impact factor: 27.287

8. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans.

Authors: Xinmei Zhang; Dennis C Y Yeung; Michal Karpisek; David Stejskal; Zhi-Guang Zhou; Feng Liu; Rachel L C Wong; Wing-Sun Chow; Annette W K Tso; Karen S L Lam; Aimin Xu
Journal: Diabetes Date: 2008-02-05 Impact factor: 9.461

9. Obesity alters gut microbial ecology.

Authors: Ruth E Ley; Fredrik Bäckhed; Peter Turnbaugh; Catherine A Lozupone; Robin D Knight; Jeffrey I Gordon
Journal: Proc Natl Acad Sci U S A Date: 2005-07-20 Impact factor: 11.205

10. A role for fibroblast growth factor 19 and bile acids in diabetes remission after Roux-en-Y gastric bypass.

Authors: Glenn S Gerhard; Amanda M Styer; G Craig Wood; Stephen L Roesch; Anthony T Petrick; Jon Gabrielsen; William E Strodel; Christopher D Still; George Argyropoulos
Journal: Diabetes Care Date: 2013-07 Impact factor: 19.112

14 in total

Review 1. Ghrelin, CCK, GLP-1, and PYY(3-36): Secretory Controls and Physiological Roles in Eating and Glycemia in Health, Obesity, and After RYGB.

Authors: Robert E Steinert; Christine Feinle-Bisset; Lori Asarian; Michael Horowitz; Christoph Beglinger; Nori Geary
Journal: Physiol Rev Date: 2017-01 Impact factor: 37.312

Review 2. Changes in Bile Acid Metabolism, Transport, and Signaling as Central Drivers for Metabolic Improvements After Bariatric Surgery.

Authors: Matthew G Browning; Bernardo M Pessoa; Jad Khoraki; Guilherme M Campos
Journal: Curr Obes Rep Date: 2019-06

Review 3. Treatment of Obesity: Weight Loss and Bariatric Surgery.

Authors: Bruce M Wolfe; Elizaveta Kvach; Robert H Eckel
Journal: Circ Res Date: 2016-05-27 Impact factor: 17.367

Review 4. Proceedings of the 2017 ASPEN Research Workshop-Gastric Bypass: Role of the Gut.

Authors: Ajay Kumar Jain; Carel W le Roux; Puneet Puri; Ali Tavakkoli; Nana Gletsu-Miller; Blandine Laferrère; Richard Kellermayer; John K DiBaise; Robert G Martindale; Bruce M Wolfe
Journal: JPEN J Parenter Enteral Nutr Date: 2018-02 Impact factor: 4.016

Review 5. Meal patterns after bariatric surgery in mice and rats.

Authors: Harsh Shah; Andrew C Shin
Journal: Appetite Date: 2019-06-29 Impact factor: 3.868

Review 6. Improved glucose metabolism following bariatric surgery is associated with increased circulating bile acid concentrations and remodeling of the gut microbiome.

Authors: Lukasz Kaska; Tomasz Sledzinski; Agnieszka Chomiczewska; Agnieszka Dettlaff-Pokora; Julian Swierczynski
Journal: World J Gastroenterol Date: 2016-10-21 Impact factor: 5.742