Literature DB >> 26335359

Estrogenicity of novel phase I and phase II metabolites of zearalenone and cis-zearalenone.

Sarah S Drzymala1, Jennifer Binder2, Antje Brodehl1, Martin Penkert3, Mark Rosowski2, Leif-Alexander Garbe4, Matthias Koch5.   

Abstract

Zearalenone and its cis-isomer, cis-zearalenone, are nonsteroidal mycotoxins that elicit an estrogenic response upon binding to the estrogen receptor. This study compares the estrogenicity of eleven congeners including novel metabolites as 15-OH-zearalenone, zearalenone-14-sulfate, α-cis-zearalenol and β-cis-zearalenol using the E-Screen assay. Overall, a change in the configuration from trans to cis retains significant estrogenic activity. In contrast, alterations of the aromatic moiety including hydroxylation and sulfation showed a markedly decreased estrogenicity when compared to zearalenone.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  E-screen assay; Estrogenicity; Isomerization; MCF-7; Mycotoxin; Zearalenone

Mesh：

Substances：

Year:  2015        PMID： 26335359     DOI： 10.1016/j.toxicon.2015.08.027

Source DB:  PubMed          Journal:  Toxicon        ISSN： 0041-0101            Impact factor:   3.033


  17 in total

1.  Biodegradation and biodetoxification of Fusarium mycotoxins by Sphaerodes mycoparasitica.

Authors:  Seon Hwa Kim; Vladimir Vujanovic
Journal:  AMB Express       Date:  2017-07-06       Impact factor: 3.298

Review 2.  Do Plant-Bound Masked Mycotoxins Contribute to Toxicity?

Authors:  Silvia W Gratz
Journal:  Toxins (Basel)       Date:  2017-02-28       Impact factor: 4.546

3.  Metabolism of Zearalenone and Its Major Modified Forms in Pigs.

Authors:  Sabina B Binder; Heidi E Schwartz-Zimmermann; Elisabeth Varga; Gerlinde Bichl; Herbert Michlmayr; Gerhard Adam; Franz Berthiller
Journal:  Toxins (Basel)       Date:  2017-02-08       Impact factor: 4.546

Review 4.  Toxicodynamics of Mycotoxins in the Framework of Food Risk Assessment-An In Silico Perspective.

Authors:  Luca Dellafiora; Chiara Dall'Asta; Gianni Galaverna
Journal:  Toxins (Basel)       Date:  2018-01-23       Impact factor: 4.546

5.  Synthesis and Structural Identification of a Biaryl Ether-Linked Zearalenone Dimer.

Authors:  Julia Keller; Luisa Hantschke; Hajo Haase; Matthias Koch
Journal:  Molecules       Date:  2018-10-12       Impact factor: 4.411

6.  Volumetric Absorptive Microsampling as an Alternative Tool for Biomonitoring of Multi-Mycotoxin Exposure in Resource-Limited Areas.

Authors:  Arnau Vidal; Lidia Belova; Christophe Stove; Marthe De Boevre; Sarah De Saeger
Journal:  Toxins (Basel)       Date:  2021-05-11       Impact factor: 4.546

7.  In Vitro Evaluation of the Individual and Combined Cytotoxic and Estrogenic Effects of Zearalenone, Its Reduced Metabolites, Alternariol, and Genistein.

Authors:  Adrienn Balázs; Zelma Faisal; Rita Csepregi; Tamás Kőszegi; Balázs Kriszt; István Szabó; Miklós Poór
Journal:  Int J Mol Sci       Date:  2021-06-11       Impact factor: 5.923

8.  Enzymatic Degradation of Multiple Major Mycotoxins by Dye-Decolorizing Peroxidase from Bacillus subtilis.

Authors:  Xing Qin; Xiaoyun Su; Tao Tu; Jie Zhang; Xiaolu Wang; Yaru Wang; Yuan Wang; Yingguo Bai; Bin Yao; Huiying Luo; Huoqing Huang
Journal:  Toxins (Basel)       Date:  2021-06-19       Impact factor: 4.546

Review 9.  Zearalenone (ZEN) in Livestock and Poultry: Dose, Toxicokinetics, Toxicity and Estrogenicity.

Authors:  Jundi Liu; Todd Applegate
Journal:  Toxins (Basel)       Date:  2020-06-07       Impact factor: 4.546

10.  Current challenges in the diagnosis of zearalenone toxicosis as illustrated by a field case of hyperestrogenism in suckling piglets.

Authors:  Isabel Hennig-Pauka; Franz-Josef Koch; Simone Schaumberger; Bettina Woechtl; Johannes Novak; Michael Sulyok; Veronika Nagl
Journal:  Porcine Health Manag       Date:  2018-09-12
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