| Literature DB >> 26334636 |
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Abstract
Entities:
Year: 2015 PMID: 26334636 PMCID: PMC4559427 DOI: 10.1371/journal.pone.0137884
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Fig 6The bursting duration in slices depends on synaptic AMPA receptors.
(A) CNQX (1 μM) eliminated the bursting reverberation. (B) Bursting duration at 0, 5, and 35 s before and after CNQX application. (*P < 0.05, compared with 0 s, Student’s paired t-test). Ratio of bursting duration at 5 s before and after CNQX application (*P < 0.05, compared with control, Student’s paired t-test, n = 4). (C) Injection of 100 pA positive current into the patched pyramidal neuron triggered bursting without depression in 5 and 35 s interval, confirming that the bursting duration is synaptically dependent.
Fig 7Calcium-dependence of reverberation bursts in large networks.
(A) Evoked burst triggered by a single stimulation of Schaffer collaterals in hippocampal slices at 5 and 35 s intervals in the presence of low [Ca2+] solution (1.3 mM [Ca2+] and 2.5 mM [Mg2+]). (B) Comparison of the burst durations for two different calcium concentrations, leading to a reduction of the 1st burst duration (35 seconds interval burst) but not the 2nd burst (5 seconds interval burst), after low [Ca2+] solution application. (*P < 0.05, compared with 0 s, Student’s paired t-test). (C) Calcium reduction is modeled by changing the parameter X, which determines the steady state value of the facilitation variable x. (D) First and second burst durations for value of X = 0.50 (control Table 1) and X = 0.4925, which describes the burst duration variations due to calcium concentration changes observed in A and B.