Guo-Chao Zhong1, Jia-Hao Cheng2, Xiang-Long Xu2, Kang Wang2. 1. Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 40010, China. Electronic address: gczhong1991@163.com. 2. Department of Urinary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 40010, China.
Abstract
BACKGROUND: Whether ever use of oral contraceptives (OCs) is associated with mortality remains unclear. OBJECTIVES: To evaluate the association between ever use of OCs and mortality. SEARCH STRATEGY: On November 2, 2014, PubMed and Embase were searched for human studies, using the terms "contraceptive," "contraceptives," "death," and "mortality." SELECTION CRITERIA: Prospective cohort studies were included that provided risk estimates on OC use and mortality, and were reported in English or Chinese. DATA COLLECTION AND ANALYSIS: A random-effects model was used to pool data. Random-effects meta-regression was used to determine whether duration of OC use and time since last OC use were associated with mortality. MAIN RESULTS: Nine studies were included. Ever use of OCs was not associated with mortality from all causes (hazard ratio [HR] 0.94; 95% CI 0.87-1.02) or breast cancer (HR 1.00; 95% CI 0.95-1.06). Neither the duration of OC use nor the time since last OC use was associated with all-cause or breast cancer mortality. In an analysis of a small number of studies, ever users were at decreased risk of mortality from ovarian cancer (HR 0.58; 95% CI 0.35-0.94). CONCLUSIONS: There is no significant association between ever use of OCs and mortality from all causes or breast cancer.
BACKGROUND: Whether ever use of oral contraceptives (OCs) is associated with mortality remains unclear. OBJECTIVES: To evaluate the association between ever use of OCs and mortality. SEARCH STRATEGY: On November 2, 2014, PubMed and Embase were searched for human studies, using the terms "contraceptive," "contraceptives," "death," and "mortality." SELECTION CRITERIA: Prospective cohort studies were included that provided risk estimates on OC use and mortality, and were reported in English or Chinese. DATA COLLECTION AND ANALYSIS: A random-effects model was used to pool data. Random-effects meta-regression was used to determine whether duration of OC use and time since last OC use were associated with mortality. MAIN RESULTS: Nine studies were included. Ever use of OCs was not associated with mortality from all causes (hazard ratio [HR] 0.94; 95% CI 0.87-1.02) or breast cancer (HR 1.00; 95% CI 0.95-1.06). Neither the duration of OC use nor the time since last OC use was associated with all-cause or breast cancer mortality. In an analysis of a small number of studies, ever users were at decreased risk of mortality from ovarian cancer (HR 0.58; 95% CI 0.35-0.94). CONCLUSIONS: There is no significant association between ever use of OCs and mortality from all causes or breast cancer.
Authors: Mark Weiser; Linda Levi; Daisy Zamora; Anat Biegon; John Paul SanGiovanni; Michael Davidson; Shimon Burshtein; Ilan Gonen; Paull Radu; Kristina Slobozean Pavalache; Igor Nastas; Rina Hemi; Timothy Ryan; John M Davis Journal: JAMA Psychiatry Date: 2019-10-01 Impact factor: 21.596