Michael Kremke1, Malene Kærslund Hansen2, Steffen Christensen3, Mariann Tang4, Jan Jesper Andreasen5, Carl-Johan Jakobsen3. 1. Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark michhinr@rm.dk. 2. Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark. 3. Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark. 4. Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark. 5. Departments of Cardiothoracic Surgery and Clinical Medicine, Aalborg University Hospital, Aalborg, Denmark.
Abstract
OBJECTIVES: Previous research suggests that platelet transfusion is associated with adverse events after coronary artery bypass grafting (CABG). The aim of the current analysis was to verify this hypothesis. METHODS: Data from 6745 consecutive patients undergoing CABG from 2006 through 2012 were collected. Patients receiving platelet transfusions intraoperatively or postoperatively in the intensive care unit were compared with control patients. To adjust for possible confounders, propensity score matching and conditional regression analyses were performed. Short-term outcomes were 30-day mortality, in-hospital myocardial infarction and stroke. Mid-term outcomes were 6-month mortality, and need for coronary angiography or repeat coronary revascularization within 6 months after surgery. Data were retrieved from the Western Denmark Heart Registry. RESULTS: Using propensity scores, 982 patients exposed to platelets were matched with 982 control patients. Platelet transfusion was associated with a higher rate of postoperative coronary angiography (adjusted odds ratio 2.34, 95% confidence interval 1.15-4.76). There was no significant association between platelet transfusion and postoperative mortality, myocardial infarction, stroke and need for repeat coronary revascularization. CONCLUSIONS: Platelet transfusion at the time of CABG is not associated with increased postoperative mortality, in-hospital myocardial infarction, stroke or need for repeat coronary revascularization.
OBJECTIVES: Previous research suggests that platelet transfusion is associated with adverse events after coronary artery bypass grafting (CABG). The aim of the current analysis was to verify this hypothesis. METHODS: Data from 6745 consecutive patients undergoing CABG from 2006 through 2012 were collected. Patients receiving platelet transfusions intraoperatively or postoperatively in the intensive care unit were compared with control patients. To adjust for possible confounders, propensity score matching and conditional regression analyses were performed. Short-term outcomes were 30-day mortality, in-hospital myocardial infarction and stroke. Mid-term outcomes were 6-month mortality, and need for coronary angiography or repeat coronary revascularization within 6 months after surgery. Data were retrieved from the Western Denmark Heart Registry. RESULTS: Using propensity scores, 982 patients exposed to platelets were matched with 982 control patients. Platelet transfusion was associated with a higher rate of postoperative coronary angiography (adjusted odds ratio 2.34, 95% confidence interval 1.15-4.76). There was no significant association between platelet transfusion and postoperative mortality, myocardial infarction, stroke and need for repeat coronary revascularization. CONCLUSIONS: Platelet transfusion at the time of CABG is not associated with increased postoperative mortality, in-hospital myocardial infarction, stroke or need for repeat coronary revascularization.
Authors: Yidan Zheng; Li Xu; Ziwen Cai; Jingrong Tu; Yuqi Liu; Yixuan Wang; Si Chen; Nianguo Dong; Fei Li Journal: Front Cardiovasc Med Date: 2022-05-20
Authors: Daniel Simancas-Racines; Ingrid Arevalo-Rodriguez; Gerard Urrutia; Diana Buitrago-Garcia; Solange Núñez-González; María José Martínez-Zapata; Eva Madrid; Xavier Bonfill; Ricardo Hidalgo-Ottolenghi Journal: Cardiol Res Pract Date: 2019-02-25 Impact factor: 1.866