Literature DB >> 26332704

Distinct Trafficking of Cell Surface and Endosomal TIM-1 to the Immune Synapse.

Meriem Echbarthi1,2, Manuela Zonca1, Rachel Mellwig3, Yannick Schwab3, Gerardo Kaplan4, Rosemarie H DeKruyff5, Pedro Roda-Navarro6, Jose M Casasnovas1.   

Abstract

The T cell costimulatory molecule TIM-1 (T cell/transmembrane, mucin and immunoglobulin domain protein 1) sorts mainly to endosomes in lymphoid cells. At difference from the cell surface protein, endosomal TIM-1 translocates to the immune synapse (IS), where it can contribute to antigen-dependent T cell costimulation. TIM-1 ligands increase the amount of cell surface protein, preventing its traffic to the IS. The bipolar sorting of TIM-1 observed during IS formation is determined by differences in its subcellular location, and probably modulates antigen-driven immune responses.
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  T-cell; TIM family; immune synapse; microscopy; protein sorting; structural immunology

Mesh：

Substances：

Year:  2015        PMID： 26332704      PMCID： PMC4607657          DOI： 10.1111/tra.12329

Source DB:  PubMed          Journal:  Traffic        ISSN： 1398-9219            Impact factor:   6.215


  41 in total

Review 1.  The distal pole complex: a novel membrane domain distal to the immunological synapse.

Authors:  Patrick Cullinan; Anne I Sperling; Janis K Burkhardt
Journal:  Immunol Rev       Date:  2002-11       Impact factor: 12.988

Review 2.  A cost-benefit analysis of the physical mechanisms of membrane curvature.

Authors:  Jeanne C Stachowiak; Frances M Brodsky; Elizabeth A Miller
Journal:  Nat Cell Biol       Date:  2013-09       Impact factor: 28.824

3.  TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation.

Authors:  Jennifer Hartt Meyers; Sumone Chakravarti; David Schlesinger; Zsolt Illes; Hanspeter Waldner; Sarah E Umetsu; James Kenny; Xin Xiao Zheng; Dale T Umetsu; Rosemarie H DeKruyff; Terry B Strom; Vijay K Kuchroo
Journal:  Nat Immunol       Date:  2005-03-27       Impact factor: 25.606

4.  Membrane phosphatidylserine regulates surface charge and protein localization.

Authors:  Tony Yeung; Gary E Gilbert; Jialan Shi; John Silvius; Andras Kapus; Sergio Grinstein
Journal:  Science       Date:  2008-01-11       Impact factor: 47.728

Review 5.  ALIX and the multivesicular endosome: ALIX in Wonderland.

Authors:  Christin Bissig; Jean Gruenberg
Journal:  Trends Cell Biol       Date:  2013-11-26       Impact factor: 20.808

6.  Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family.

Authors:  J J McIntire; S E Umetsu; O Akbari; M Potter; V K Kuchroo; G S Barsh; G J Freeman; D T Umetsu; R H DeKruyff
Journal:  Nat Immunol       Date:  2001-12       Impact factor: 25.606

Review 7.  T cell Ig and mucin domain proteins and immunity.

Authors:  Lawrence P Kane
Journal:  J Immunol       Date:  2010-03-15       Impact factor: 5.422

Review 8.  Trafficking and function of the tetraspanin CD63.

Authors:  Maaike S Pols; Judith Klumperman
Journal:  Exp Cell Res       Date:  2008-10-07       Impact factor: 3.905

9.  TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine.

Authors:  Stephanie Jemielity; Jinyize J Wang; Ying Kai Chan; Asim A Ahmed; Wenhui Li; Sheena Monahan; Xia Bu; Michael Farzan; Gordon J Freeman; Dale T Umetsu; Rosemarie H Dekruyff; Hyeryun Choe
Journal:  PLoS Pathog       Date:  2013-03-28       Impact factor: 6.823

10.  Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function.

Authors:  Sheng Xiao; Nader Najafian; Jay Reddy; Monica Albin; Chen Zhu; Eric Jensen; Jaime Imitola; Thomas Korn; Ana C Anderson; Zheng Zhang; Cristina Gutierrez; Thomas Moll; Raymond A Sobel; Dale T Umetsu; Hideo Yagita; Hisaya Akiba; Terry Strom; Mohamed H Sayegh; Rosemarie H DeKruyff; Samia J Khoury; Vijay K Kuchroo
Journal:  J Exp Med       Date:  2007-07-02       Impact factor: 14.307
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  3 in total

1.  IL-21/anti-Tim1/CD40 ligand promotes B10 activity in vitro and alleviates bone loss in experimental periodontitis in vivo.

Authors:  Yang Hu; Pei Yu; Xinbo Yu; Xingxue Hu; Toshihisa Kawai; Xiaozhe Han
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2017-06-03       Impact factor: 5.187

2.  HIV internalization into oral and genital epithelial cells by endocytosis and macropinocytosis leads to viral sequestration in the vesicles.

Authors:  Aizezi Yasen; Rossana Herrera; Kristina Rosbe; Kathy Lien; Sharof M Tugizov
Journal:  Virology       Date:  2017-12-22       Impact factor: 3.616

Review 3.  Kidney Injury Molecule 1 (KIM-1): a Multifunctional Glycoprotein and Biological Marker (Review).

Authors:  Т А Karmakova; N S Sergeeva; К Yu Kanukoev; B Ya Alekseev; А D Kaprin
Journal:  Sovrem Tekhnologii Med       Date:  2021-06-28
  3 in total

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