C Solomon1,2, K Fickenscher1, L Ormonde3, M Ranucci4. 1. CSL Behring, Marburg, Germany. 2. Department of Anesthesiology, Perioperative Medicine and General Intensive Care, Paracelsus Medical University, Salzburg, Austria. 3. Department of Anaesthesiology, Santa Maria University Hospital, Lisbon, Portugal. 4. Department of Cardiothoracic, Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy.