| Literature DB >> 26332072 |
Peter Leidinger1, Jens Treptow1, Kristine Hagens2, Jacqueline Eich2, Nicole Zehethofer2, Dominik Schwudke2, Wulf Oehlmann3, Heinrich Lünsdorf4, Oliver Goldmann4, Ulrich E Schaible5, Kurt E J Dittmar6, Claus Feldmann7.
Abstract
Isoniazid-filled Fe2 O3 hollow nanospheres (INH@Fe2 O3 , diameter <30 nm, 48 wt % INH-load) are prepared for the first time and suggested for tuberculosis therapy. After dextran-functionalization, the INH@Fe2 O3 @DEX nanocontainers show strong activity against Mycobacterium tuberculosis (M.tb.) and M.tb.-infected macrophages. The nanocontainers can be considered as "Trojan horses" and show efficient, active uptake into both M.tb.-infected macrophages and even into mycobacterial cells.Entities:
Keywords: in vitro studies; isoniazid; mycobacteria; nanocontainers; tuberculosis
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Year: 2015 PMID： 26332072 DOI： 10.1002/anie.201505493
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336