Soham P Chaudhari1, Michael B Mortazie2, Collin M Blattner3, Jessica Garelik4, Marisa Wolff5, Jaldeep Daulat6,7, Prakash J Chaudhari8. 1. a Palisades Medical Center , North Bergen , NJ , USA . 2. b Department of Dermatology , St. Joseph Mercy Hospital , Ann Arbor , MI , USA . 3. c Good Samaritan Regional Medical Center , Corvallis , OR , USA . 4. d Department of Dermatology , Albert Einstein College of Medicine , Bronx , NY , USA . 5. e Department of Dermatology , St. Barnabas Hospital , Bronx , NY , USA . 6. f Las Vegas Skin & Cancer Clinics , Las Vegas , NV , USA . 7. g Mohave Centers for Dermatology & Plastic Surgery , Kingman , AZ , USA , and. 8. h Associated Pathologists Chartered , Las Vegas , NV , USA.
Abstract
INTRODUCTION: Microcystic adnexal carcinoma (MAC) is a rare malignant cutaneous neoplasm presenting as a slow-growing, indurated nodule, papule or plaque. Clinically, the lesion can blend into the surrounding skin, obscuring borders and consequently delaying diagnosis histologically. Surgical and histologic techniques that emphasize examination of all margins may optimize management through early diagnosis and prevention of recurrences. OBJECTIVE: This review aims to assess the current surgical and histology techniques that result in lower rates of tumor recurrence and, consequently, better clinical outcomes. METHODS: A literature search of the PubMed database was conducted to identify studies examining wide local excision (WLE), Mohs micrographic surgery (MMS), radiotherapy (RT) and chemotherapy in the treatment of MAC. RESULTS: WLE had a high likelihood of positive margins and local recurrence. MMS was found to have the lowest recurrence rates. Definitive RT could be considered for elderly patients or those who are poor surgical candidates, as large surgical defects may be required to obtain free margins with either WLE or MMS. Chemotherapy was found to be ineffective. CONCLUSION: Complete margin evaluation with MMS permits complete tumor removal with subsequently low recurrence rate.
INTRODUCTION:Microcystic adnexal carcinoma (MAC) is a rare malignant cutaneous neoplasm presenting as a slow-growing, indurated nodule, papule or plaque. Clinically, the lesion can blend into the surrounding skin, obscuring borders and consequently delaying diagnosis histologically. Surgical and histologic techniques that emphasize examination of all margins may optimize management through early diagnosis and prevention of recurrences. OBJECTIVE: This review aims to assess the current surgical and histology techniques that result in lower rates of tumor recurrence and, consequently, better clinical outcomes. METHODS: A literature search of the PubMed database was conducted to identify studies examining wide local excision (WLE), Mohs micrographic surgery (MMS), radiotherapy (RT) and chemotherapy in the treatment of MAC. RESULTS: WLE had a high likelihood of positive margins and local recurrence. MMS was found to have the lowest recurrence rates. Definitive RT could be considered for elderly patients or those who are poor surgical candidates, as large surgical defects may be required to obtain free margins with either WLE or MMS. Chemotherapy was found to be ineffective. CONCLUSION: Complete margin evaluation with MMS permits complete tumor removal with subsequently low recurrence rate.
Authors: Iga Płachta; Marcin Kleibert; Anna M Czarnecka; Mateusz Spałek; Anna Szumera-Ciećkiewicz; Piotr Rutkowski Journal: Int J Mol Sci Date: 2021-05-11 Impact factor: 5.923