Literature DB >> 26331889

Streptozotocin-Induced Diabetic Models in Mice and Rats.

Brian L Furman1.   

Abstract

Streptozotocin (STZ) is an antibiotic that produces pancreatic islet β-cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this unit are protocols for producing STZ-induced insulin deficiency and hyperglycemia in mice and rats. Also described are protocols for creating animal models for type 2 diabetes using STZ. These animals are employed for assessing the pathological consequences of diabetes and for screening potential therapies for the treatment of this condition.
Copyright © 2015 John Wiley & Sons, Inc.

Entities:  

Keywords:  high-fat; hyperglycemia; insulin deficiency; insulin resistance; insulitis; mouse or rat; nicotinamide; streptozotocin; type 1 diabetes mellitus; type 2 diabetes mellitus

Mesh：

Substances：

Year:  2015        PMID： 26331889     DOI： 10.1002/0471141755.ph0547s70

Source DB:  PubMed          Journal:  Curr Protoc Pharmacol        ISSN： 1934-8282


  174 in total

1.  NMR-based metabolomics reveals brain region-specific metabolic alterations in streptozotocin-induced diabetic rats with cognitive dysfunction.

Authors:  Hong Zheng; Qiuting Lin; Dan Wang; Pengtao Xu; Liangcai Zhao; Wenyi Hu; Guanghui Bai; Zhihan Yan; Hongchang Gao
Journal:  Metab Brain Dis       Date:  2017-01-09       Impact factor: 3.584

2.  Arsenic exposure intensifies glycogen nephrosis in diabetic rats.

Authors:  Marcela Nascimento Sertorio; Ana Cláudia Ferreira Souza; Daniel Silva Sena Bastos; Felipe Couto Santos; Luiz Otávio Guimarães Ervilha; Kenner Morais Fernandes; Leandro Licursi de Oliveira; Mariana Machado-Neves
Journal:  Environ Sci Pollut Res Int       Date:  2019-03-07       Impact factor: 4.223

3.  High glucose reduces megalin-mediated albumin endocytosis in renal proximal tubule cells through protein kinase B O-GlcNAcylation.

Authors:  Diogo de Barros Peruchetti; Rodrigo Pacheco Silva-Aguiar; Gabriela Marques Siqueira; Wagner Barbosa Dias; Celso Caruso-Neves
Journal:  J Biol Chem       Date:  2018-06-05       Impact factor: 5.157

Review 4.  Effects of Propolis Extract and Propolis-Derived Compounds on Obesity and Diabetes: Knowledge from Cellular and Animal Models.

Authors:  Hiroshi Kitamura
Journal:  Molecules       Date:  2019-12-01       Impact factor: 4.411

5.  High glucose-mediated PICALM and mTORC1 modulate processing of amyloid precursor protein via endosomal abnormalities.

Authors:  Chang Woo Chae; Hyun Jik Lee; Gee Euhn Choi; Young Hyun Jung; Jun Sung Kim; Jae Ryong Lim; Seo Yihl Kim; In Koo Hwang; Je Kyung Seong; Ho Jae Han
Journal:  Br J Pharmacol       Date:  2020-07-14       Impact factor: 8.739

6.  Function-first ligandomics for ocular vascular research and drug target discovery.

Authors:  Xin Rong; Hong Tian; Liu Yang; Wei Li
Journal:  Exp Eye Res       Date:  2019-03-21       Impact factor: 3.467

7.  Prediction of cellular targets in diabetic kidney diseases with single-cell transcriptomic analysis of db/db mouse kidneys.

Authors:  Chenhua Wu; Yingjun Tao; Nan Li; Jingjin Fei; Yurong Wang; Jie Wu; Harvest F Gu
Journal:  J Cell Commun Signal       Date:  2022-07-09       Impact factor: 5.782

8.  Metabolic effects of carvedilol through β-arrestin proteins: investigations in a streptozotocin-induced diabetes rat model and in C2C12 myoblasts.

Authors:  Berna Güven; Zümra Kara; Arzu Onay-Beşikci
Journal:  Br J Pharmacol       Date:  2020-11-15       Impact factor: 8.739

9.  Grape seed proanthocyanidin extract and insulin prevents cognitive decline in type 1 diabetic rat by impacting Bcl-2 and Bax in the prefrontal cortex.

Authors:  Raja Sekhar Sanna; Subramanyam Muthangi; Chandrasekhar Sagar B K; Sambe Asha Devi
Journal:  Metab Brain Dis       Date:  2018-10-03       Impact factor: 3.584

10.  Diabetic nephropathy in mice is aggravated by the absence of podocyte IRE1 and is correlated with reduced kidney ADH1 expression.

Authors:  Liping Xie; Kaifeng Guo; Sijia Lu; Ning Wang; Yanping Wang; Haibing Chen; Junli Liu; Weiping Jia
Journal:  Ann Transl Med       Date:  2021-04
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