Katherine R Marks1,2, Erika Pike1,2, William W Stoops1,2,3, Craig R Rush1,2,3. 1. Department of Psychology, University of Kentucky College of Arts and Sciences, Lexington, Kentucky. 2. Department of Behavioral Science, University of Kentucky College of Medicine, Lexington, Kentucky. 3. Department of Psychiatry, University of Kentucky College of Medicine, Lexington, Kentucky.
Abstract
BACKGROUND:Alcohol consumption is a known antecedent to cocaine relapse. Through associative conditioning, it is hypothesized that alcohol increases incentive motivation for cocaine and thus the salience of cocaine-related cues, which are important in maintaining drug-taking behavior. Cocaine-using individuals display a robust cocaine cue attentional bias as measured by fixation time during the visual probe task. The purpose of this study was to evaluate the influence of alcohol administration on cocaine cue attentional bias using eye-tracking technology to directly measure attentional allocation. METHODS:Twenty current cocaine users completed a double-blind, placebo-controlled, within-subjects study that tested the effect of 3 doses of alcohol (0.00, 0.325, and 0.65 g/kg) on cocaine cue attentional bias using the visual probe task with eye-tracking technology. The participant-rated and physiological effects of alcohol were also assessed. RESULTS: Participants displayed a robust cocaine cue attentional bias following both placebo and alcohol administration as measured by fixation time, but not response time. Alcohol administration did not influence cocaine cue attentional bias, but increased craving for cocaine in a dose-dependent manner. Alcohol produced prototypic psychomotor and participant-rated effects. CONCLUSIONS:Alcohol administration increases cocaine craving but not cocaine cue attentional bias. Alcohol-induced cocaine craving suggests that alcohol increases incentive motivation for cocaine but not the salience of cocaine-related cues.
RCT Entities:
BACKGROUND:Alcohol consumption is a known antecedent to cocaine relapse. Through associative conditioning, it is hypothesized that alcohol increases incentive motivation for cocaine and thus the salience of cocaine-related cues, which are important in maintaining drug-taking behavior. Cocaine-using individuals display a robust cocaine cue attentional bias as measured by fixation time during the visual probe task. The purpose of this study was to evaluate the influence of alcohol administration on cocaine cue attentional bias using eye-tracking technology to directly measure attentional allocation. METHODS: Twenty current cocaine users completed a double-blind, placebo-controlled, within-subjects study that tested the effect of 3 doses of alcohol (0.00, 0.325, and 0.65 g/kg) on cocaine cue attentional bias using the visual probe task with eye-tracking technology. The participant-rated and physiological effects of alcohol were also assessed. RESULTS:Participants displayed a robust cocaine cue attentional bias following both placebo and alcohol administration as measured by fixation time, but not response time. Alcohol administration did not influence cocaine cue attentional bias, but increased craving for cocaine in a dose-dependent manner. Alcohol produced prototypic psychomotor and participant-rated effects. CONCLUSIONS:Alcohol administration increases cocaine craving but not cocaine cue attentional bias. Alcohol-induced cocaine craving suggests that alcohol increases incentive motivation for cocaine but not the salience of cocaine-related cues.
Authors: Katherine R Marks; Walter Roberts; William W Stoops; Erika Pike; Mark T Fillmore; Craig R Rush Journal: Addiction Date: 2014-07-02 Impact factor: 6.526
Authors: Robert F Leeman; Cendrine D Robinson; Andrew J Waters; Mehmet Sofuoglu Journal: Exp Clin Psychopharmacol Date: 2014-09-15 Impact factor: 3.157
Authors: Ellen C Caniglia; Elizabeth R Stevens; Maria Khan; Kailyn E Young; Kaoon Ban; Brandon D L Marshall; Natalie E Chichetto; Julie R Gaither; Stephen Crystal; Eva Jennifer Edelman; David A Fiellin; Adam J Gordon; Kendall J Bryant; Janet Tate; Amy C Justice; Ronald Scott Braithwaite Journal: Alcohol Clin Exp Res Date: 2020-10-08 Impact factor: 3.928
Authors: Melvyn W B Zhang; Jiangbo Ying; Tracey Wing; Guo Song; Daniel S S Fung; Helen E Smith Journal: Front Psychiatry Date: 2018-08-15 Impact factor: 4.157
Authors: Maria R Khan; Kailyn E Young; Ellen C Caniglia; David A Fiellin; Stephen A Maisto; Brandon D L Marshall; E Jennifer Edelman; Julie R Gaither; Natalie E Chichetto; Janet Tate; Kendall J Bryant; MacRegga Severe; Elizabeth R Stevens; Amy Justice; Scott R Braithwaite Journal: JAMA Netw Open Date: 2020-03-02