Youxue Zhang1, Feng Liu1, Heng Chen1, Meiling Li1, Xujun Duan1, Bing Xie2, Huafu Chen3. 1. Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China. 2. Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China; Department of Anatomy, Third Military Medical University, 30 Gaotanyan Street, Chongqing 400038, China. Electronic address: xiebing6@gmail.com. 3. Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China. Electronic address: chenhf@uestc.edu.cn.
Abstract
BACKGROUND: A large number of previous neuroimaging studies have explored the functional alterations of post-traumatic stress disorder (PTSD). However, abnormalities in the functional architecture of resting-state networks in PTSD were rarely elucidated. METHODS: This study used independent component analysis to explore the resting-state intranetwork and internetwork functional connectivity differences between 20 PTSD patients and 20 matched healthy controls (HCs). RESULTS: Selective alterations of intranetwork and internetwork intrinsic functional connectivities were found in the PTSD patients. Compared with HCs, the PTSD patients exhibited significantly decreased network connectivity within the anterior default mode network, posterior default mode network (pDMN), salience network (SN), sensory-motor network, and auditory network. Furthermore, the PTSD patients exhibited increased internetwork connectivity between SN and pDMN. LIMITATIONS: This study lacked recruitment of trauma-exposed HCs, which limits our ability to determine whether the alterations are caused by PTSD or trauma exposure. CONCLUSION: The findings suggested that the PTSD patients exhibited abnormal functional connectivity at the brain network level. Notably, the enhanced internetwork connectivity between SN and pDMN in the PTSD patients may be associated with hyperarousal and heightened anxiety in PTSD.
BACKGROUND: A large number of previous neuroimaging studies have explored the functional alterations of post-traumatic stress disorder (PTSD). However, abnormalities in the functional architecture of resting-state networks in PTSD were rarely elucidated. METHODS: This study used independent component analysis to explore the resting-state intranetwork and internetwork functional connectivity differences between 20 PTSDpatients and 20 matched healthy controls (HCs). RESULTS: Selective alterations of intranetwork and internetwork intrinsic functional connectivities were found in the PTSDpatients. Compared with HCs, the PTSDpatients exhibited significantly decreased network connectivity within the anterior default mode network, posterior default mode network (pDMN), salience network (SN), sensory-motor network, and auditory network. Furthermore, the PTSDpatients exhibited increased internetwork connectivity between SN and pDMN. LIMITATIONS: This study lacked recruitment of trauma-exposed HCs, which limits our ability to determine whether the alterations are caused by PTSD or trauma exposure. CONCLUSION: The findings suggested that the PTSDpatients exhibited abnormal functional connectivity at the brain network level. Notably, the enhanced internetwork connectivity between SN and pDMN in the PTSDpatients may be associated with hyperarousal and heightened anxiety in PTSD.
Authors: Amit Etkin; Adi Maron-Katz; Wei Wu; Gregory A Fonzo; Julia Huemer; Petra E Vértes; Brian Patenaude; Jonas Richiardi; Madeleine S Goodkind; Corey J Keller; Jaime Ramos-Cejudo; Yevgeniya V Zaiko; Kathy K Peng; Emmanuel Shpigel; Parker Longwell; Russ T Toll; Allison Thompson; Sanno Zack; Bryan Gonzalez; Raleigh Edelstein; Jingyun Chen; Irene Akingbade; Elizabeth Weiss; Roland Hart; Silas Mann; Kathleen Durkin; Steven H Baete; Fernando E Boada; Afia Genfi; Jillian Autea; Jennifer Newman; Desmond J Oathes; Steven E Lindley; Duna Abu-Amara; Bruce A Arnow; Nicolas Crossley; Joachim Hallmayer; Silvia Fossati; Barbara O Rothbaum; Charles R Marmar; Edward T Bullmore; Ruth O'Hara Journal: Sci Transl Med Date: 2019-04-03 Impact factor: 17.956
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Authors: Gregory A Fonzo; Madeleine S Goodkind; Desmond J Oathes; Yevgeniya V Zaiko; Meredith Harvey; Kathy K Peng; M Elizabeth Weiss; Allison L Thompson; Sanno E Zack; Steven E Lindley; Bruce A Arnow; Booil Jo; Barbara O Rothbaum; Amit Etkin Journal: Biol Psychiatry Date: 2020-12-08 Impact factor: 13.382