Literature DB >> 26331603

Redox Modulation by Reversal of the Mitochondrial Nicotinamide Nucleotide Transhydrogenase.

Michael P Murphy1.   

Abstract

The mitochondrial nicotinamide nucleotide transhydrogenase (NNT) uses the protonmotive force to transfer electrons from NADH to NADP, thereby maintaining the NADP/NADPH pool reduced to protect mitochondria from oxidative damage. In this issue, Nickel et al. (2015) show that NNT also operates in reverse, oxidizing the NADP/NADPH pool, thereby disrupting antioxidant defense.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 26331603     DOI： 10.1016/j.cmet.2015.08.012

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


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