Literature DB >> 26330662

Anti-Lymphoma Monoclonal Antibodies: Making Better Antibodies and Making Antibodies Better.

George J Weiner1.   

Abstract

Monoclonal antibodies (mAbs) are highly effective anti-cancer agents; however, there is still considerable room for improving their therapeutic impact. Understanding the mechanisms of action of anti-cancer mAbs, and modifying mAb structure based on this understanding, is leading to the design and testing of more effective mAbs.

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Year:  2015        PMID: 26330662      PMCID: PMC4530715     

Source DB:  PubMed          Journal:  Trans Am Clin Climatol Assoc        ISSN: 0065-7778


  6 in total

1.  CD16 polymorphisms and NK activation induced by monoclonal antibody-coated target cells.

Authors:  Julie A Bowles; George J Weiner
Journal:  J Immunol Methods       Date:  2005-09       Impact factor: 2.303

Review 2.  Rituximab: mechanism of action.

Authors:  George J Weiner
Journal:  Semin Hematol       Date:  2010-04       Impact factor: 3.851

3.  Rituximab infusion induces NK activation in lymphoma patients with the high-affinity CD16 polymorphism.

Authors:  Suresh Veeramani; Siao-Yi Wang; Christopher Dahle; Sue Blackwell; Laura Jacobus; Tina Knutson; Anna Button; Brian K Link; George J Weiner
Journal:  Blood       Date:  2011-07-18       Impact factor: 22.113

4.  GA101 induces NK-cell activation and antibody-dependent cellular cytotoxicity more effectively than rituximab when complement is present.

Authors:  Delila J Kern; Britnie R James; Sue Blackwell; Christian Gassner; Christian Klein; George J Weiner
Journal:  Leuk Lymphoma       Date:  2013-04-16

Review 5.  Complement and cellular cytotoxicity in antibody therapy of cancer.

Authors:  Siao-Yi Wang; George Weiner
Journal:  Expert Opin Biol Ther       Date:  2008-06       Impact factor: 4.388

6.  Depletion of the C3 component of complement enhances the ability of rituximab-coated target cells to activate human NK cells and improves the efficacy of monoclonal antibody therapy in an in vivo model.

Authors:  Siao-Yi Wang; Suresh Veeramani; Emilian Racila; Jeffrey Cagley; David C Fritzinger; Carl-Wilhelm Vogel; William St John; George J Weiner
Journal:  Blood       Date:  2009-10-05       Impact factor: 22.113

  6 in total

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