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Literature DB >> 26330204

Low-dose aspirin use does not diminish the immune response to monovalent H1N1 influenza vaccine in older adults.

M L Jackson¹, A Bellamy², M Wolff², H Hill², L A Jackson¹.

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) may inhibit antibody production by peripheral blood mononuclear cells; one consequence of this could be decreased effectiveness of vaccines in NSAID users. Because many older adults use low-dose aspirin for primary or secondary prevention of coronary events, any inhibitory effect of aspirin on vaccine immune response could reduce the benefits of vaccination programmes in older adults. We tested whether immune response to vaccination differed between users vs. non-users of low-dose aspirin, using data from four randomized trials of monovalent 2009 pandemic influenza A(H1N1) vaccine. Geometric mean haemagglutination inhibition antibody titres were not significantly lower in low-dose aspirin users compared to non-users. Our results provide reassurance that influenza vaccination effectiveness is probably not reduced in older adults taking chronic low-dose aspirin.

Entities: Chemical Disease Species

Keywords: Anti-inflammatory agents; human influenza; non-steroidal; vaccines

Mesh：

Substances：

Year: 2015 PMID： 26330204 PMCID： PMC4737981 DOI： 10.1017/S0950268815002058

Source DB: PubMed Journal: Epidemiol Infect ISSN： 0950-2688 Impact factor: 2.451

11 in total

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3. Phase 2 assessment of the safety and immunogenicity of two inactivated pandemic monovalent H1N1 vaccines in adults as a component of the U.S. pandemic preparedness plan in 2009.

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Journal: Clin Diagn Lab Immunol Date: 1994-03

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