Tomoaki Shiba1, Tetsuya Sugiyama2, Yuichi Hori3, Tadashi Matsumoto3, Takatoshi Maeno4, Mao Takahashi5. 1. Department of Ophthalmology, School of Medicine, Toho University, 6-11-1, Omori-Nishi, Ota-ku, Tokyo, 143-8541, Japan. tomoaki-s@med.toho-u.ac.jp. 2. Nakano Eye Clinic of Kyoto Medical Co-operative, 2, Kyoto, Japan. 3. Department of Ophthalmology, School of Medicine, Toho University, 6-11-1, Omori-Nishi, Ota-ku, Tokyo, 143-8541, Japan. 4. Department of Ophthalmology, Toho University Sakura Medical Center, Chiba, Japan. 5. Cardiovascular Center, Toho University Sakura Medical Center, Chiba, Japan.
Abstract
PROPOSE: To evaluate relationships between optic nerve head (ONH) circulation by laser speckle flowgraphy (LSFG), and secretion levels of plasma norepinephrine (NE), plasma renin activity (PRA), plasma aldosterone concentration (PAC), and plasma cortisol. METHOD: Forty subjects were included in the study. The mean blur rates (MBR) throughout the ONH (MBR-all), in the tissue (MBR-tissue), and in vessels (MBR-vessel) were analyzed. In 29 subjects the following parameters were evaluated: plasma NE and ONH circulation in the evening and morning (Δ plasma NE, Δ MBR-all, -tissue, -vessel, and Δ area ratio of blood stream). RESULTS: Plasma NE was significantly correlated with MBR-all (r = 0.39, P = 0.01) and MBR-vessel (r = 0.51, P = 0.0008). Plasma cortisol was significantly correlated with MBR-vessel (r =0.35, P = 0.03). The PRA (r = 0.31, P = 0.05) and PAC (r = 0.31, P = 0.05) tended to correlate with MBR-vessel. The multiple regression analysis revealed that plasma NE, PAC, and ocular perfusion pressure (OPP) were identified as factors contributing independently to the MBR-vessel (plasma NE: standard regression = 0.48, t-value = 3.12, P = 0.004; PAC: 0.43, 3.10, 0.04; OPP: 0.58, 2.34, 0.03, r = 0.71). Positive correlations between Δ plasma NE and Δ MBR-all (r = 0.46, P = 0.01), Δ MBR-tissue (0.38, 0.04), Δ MBR-vessel (0.41, 0.03), and Δ area ratio of blood stream (0.38, 0.04) were observed. CONCLUSION: Our results clarified that the measurements of ONH circulation by LSFG is reflecting the plasma secretion levels of vasoactive mediators.
PROPOSE: To evaluate relationships between optic nerve head (ONH) circulation by laser speckle flowgraphy (LSFG), and secretion levels of plasma norepinephrine (NE), plasma renin activity (PRA), plasma aldosterone concentration (PAC), and plasma cortisol. METHOD: Forty subjects were included in the study. The mean blur rates (MBR) throughout the ONH (MBR-all), in the tissue (MBR-tissue), and in vessels (MBR-vessel) were analyzed. In 29 subjects the following parameters were evaluated: plasma NE and ONH circulation in the evening and morning (Δ plasma NE, Δ MBR-all, -tissue, -vessel, and Δ area ratio of blood stream). RESULTS: Plasma NE was significantly correlated with MBR-all (r = 0.39, P = 0.01) and MBR-vessel (r = 0.51, P = 0.0008). Plasma cortisol was significantly correlated with MBR-vessel (r =0.35, P = 0.03). The PRA (r = 0.31, P = 0.05) and PAC (r = 0.31, P = 0.05) tended to correlate with MBR-vessel. The multiple regression analysis revealed that plasma NE, PAC, and ocular perfusion pressure (OPP) were identified as factors contributing independently to the MBR-vessel (plasma NE: standard regression = 0.48, t-value = 3.12, P = 0.004; PAC: 0.43, 3.10, 0.04; OPP: 0.58, 2.34, 0.03, r = 0.71). Positive correlations between Δ plasma NE and Δ MBR-all (r = 0.46, P = 0.01), Δ MBR-tissue (0.38, 0.04), Δ MBR-vessel (0.41, 0.03), and Δ area ratio of blood stream (0.38, 0.04) were observed. CONCLUSION: Our results clarified that the measurements of ONH circulation by LSFG is reflecting the plasma secretion levels of vasoactive mediators.
Authors: Andreas Tomaschitz; Stefan Pilz; Eberhard Ritz; Andreas Meinitzer; Bernhard O Boehm; Winfried März Journal: Eur Heart J Date: 2010-03-02 Impact factor: 29.983
Authors: Nikolaus Luft; Piotr A Wozniak; Gerold C Aschinger; Klemens Fondi; Ahmed M Bata; René M Werkmeister; Doreen Schmidl; Katarzyna J Witkowska; Matthias Bolz; Gerhard Garhöfer; Leopold Schmetterer Journal: PLoS One Date: 2016-12-13 Impact factor: 3.240