Literature DB >> 26329914

[Neuroprotection by noble gases: New developments and insights].

A V Fahlenkamp1, R Rossaint2, M Coburn2.   

Abstract

Noble gases are chemically inert elements, some of which exert biological activity. Experimental neuroprotection in particular has been widely shown for xenon, argon and helium. The underlying mechanisms of action are not yet fully understood. Besides an interference with neuronal ion-gated channels and cellular signaling pathways as well as anti-apoptotic effects, the modulation of neuroinflammation seems to play a crucial role. This review presents the current knowledge on neuroprotection by noble gases with a focus on interactions with the neuronal-glial network and neuroinflammation and the perspectives on clinical applications.

Entities:  

Keywords:  Apoptosis; Inflammation; Neuroglia; Neuron; Neuroprotective agents

Mesh：

Substances：

Year:  2015        PMID： 26329914     DOI： 10.1007/s00101-015-0079-6

Source DB:  PubMed          Journal:  Anaesthesist        ISSN： 0003-2417            Impact factor:   1.041


  50 in total

1.  Prevention of neurotoxicity in hypoxic cortical neurons by the noble gas xenon.

Authors:  Christian Petzelt; Per Blom; Wolfgang Schmehl; Jana Müller; Wolfgang J Kox
Journal:  Life Sci       Date:  2003-03-14       Impact factor: 5.037

2.  Xenon provides short-term neuroprotection in neonatal rats when administered after hypoxia-ischemia.

Authors:  John Dingley; James Tooley; Helen Porter; Marianne Thoresen
Journal:  Stroke       Date:  2005-12-22       Impact factor: 7.914

3.  The protective profile of argon, helium, and xenon in a model of neonatal asphyxia in rats.

Authors:  Lei Zhuang; Ting Yang; Hailin Zhao; António Rei Fidalgo; Marcela P Vizcaychipi; Robert D Sanders; Buwei Yu; Masao Takata; Mark R Johnson; Daqing Ma
Journal:  Crit Care Med       Date:  2012-06       Impact factor: 7.598

4.  Xenon enhances hypothermic neuroprotection in asphyxiated newborn pigs.

Authors:  Elavazhagan Chakkarapani; John Dingley; Xun Liu; Nicholas Hoque; Kristian Aquilina; Helen Porter; Marianne Thoresen
Journal:  Ann Neurol       Date:  2010-09       Impact factor: 10.422

5.  Xenon preconditioning reduces brain damage from neonatal asphyxia in rats.

Authors:  Daqing Ma; Mahmuda Hossain; Garry K J Pettet; Yan Luo; Ta Lim; Stanislav Akimov; Robert D Sanders; Nicholas P Franks; Mervyn Maze
Journal:  J Cereb Blood Flow Metab       Date:  2006-02       Impact factor: 6.200

6.  The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury.

Authors:  Mark Coburn; Mervyn Maze; Nicholas P Franks
Journal:  Crit Care Med       Date:  2008-02       Impact factor: 7.598

7.  Heliox and oxygen reduce infarct volume in a rat model of focal ischemia.

Authors:  Yi Pan; Haibo Zhang; Donald R VanDeripe; Salvador Cruz-Flores; W Michael Panneton
Journal:  Exp Neurol       Date:  2007-03-30       Impact factor: 5.330

8.  Xenon augmented hypothermia reduces early lactate/N-acetylaspartate and cell death in perinatal asphyxia.

Authors:  Stuart Faulkner; Alan Bainbridge; Takenori Kato; Manigandan Chandrasekaran; Andrew B Kapetanakis; Mariya Hristova; Mengyan Liu; Samantha Evans; Enrico De Vita; Dorottya Kelen; Robert D Sanders; A David Edwards; Mervyn Maze; Ernest B Cady; Gennadij Raivich; Nicola J Robertson
Journal:  Ann Neurol       Date:  2011-06-14       Impact factor: 10.422

9.  Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage.

Authors:  Siyuan P Sheng; Beilei Lei; Michael L James; Christopher D Lascola; Talaignair N Venkatraman; Jin Yong Jung; Mervyn Maze; Nicholas P Franks; Robert D Pearlstein; Huaxin Sheng; David S Warner
Journal:  Anesthesiology       Date:  2012-12       Impact factor: 7.892

10.  Argon: neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury.

Authors:  Philip D Loetscher; Jan Rossaint; Rolf Rossaint; Joachim Weis; Michael Fries; Astrid Fahlenkamp; Yu-Mi Ryang; Oliver Grottke; Mark Coburn
Journal:  Crit Care       Date:  2009-12-17       Impact factor: 9.097
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  5 in total

1.  [Good to know: young scientists' research topics].

Authors:  V S Eckle; S N Stehr
Journal:  Anaesthesist       Date:  2015-10       Impact factor: 1.041

Review 2.  [Cardioprotection in cardiac surgical patients : Everything good comes from the heart].

Authors:  C Stoppe; P Meybohm; M Coburn; A Goetzenich
Journal:  Anaesthesist       Date:  2016-03       Impact factor: 1.041

3.  Timely and Appropriate Administration of Inhaled Argon Provides Better Outcomes for tMCAO Mice: A Controlled, Randomized, and Double-Blind Animal Study.

Authors:  Juan He; Ke Xue; Jiayi Liu; Jin-Hua Gu; Bin Peng; Lihua Xu; Guohua Wang; Zhenglin Jiang; Xia Li; Yunfeng Zhang
Journal:  Neurocrit Care       Date:  2022-02-08       Impact factor: 3.532

4.  Inhaled Argon Impedes Hepatic Regeneration after Ischemia/Reperfusion Injury in Rats.

Authors:  Sophia M Schmitz; Henriette Dohmeier; Christian Stoppe; Patrick H Alizai; Sandra Schipper; Ulf P Neumann; Mark Coburn; Tom F Ulmer
Journal:  Int J Mol Sci       Date:  2020-07-30       Impact factor: 5.923

Review 5.  Update of the organoprotective properties of xenon and argon: from bench to beside.

Authors:  Roehl Anna; Rossaint Rolf; Coburn Mark
Journal:  Intensive Care Med Exp       Date:  2020-02-24
  5 in total

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