BACKGROUND/AIMS: Non-alcoholic fatty liver disease is a spectrum of clinical conditions, including simple steatosis and non-alcoholic steatohepatitis (NASH). The aim of the study is to evaluate the tissue inhibitors of metalloproteinase-1 and 2 (TIMPs) as noninvasive predictors of NASH. METHODS: Three groups were included in the study. Obese patients (n = 30) with normal liver enzymes were included in group I and obese patients (n = 30) with elevated liver enzymes with liver biopsy-based diagnosis of NASH were included in group II. Age-matched subjects (n = 30) formed the control as group III. The lipid profile, liver enzyme levels and levels of TIMPs were compared among all the patients and subjects. RESULTS: Comparison of groups I and II showed significantly elevated levels of TIMP-1 and TIMP-2 in group II as compared to group I (p < 0.05). Similarly, comparison between groups II and III showed significantly increased levels of TIMP-1 and TIMP-2 in group II as compared to group III (p < 0.05). TIMP-1 (sensitivity 96.7%, specificity 100%) and TIMP-2 (sensitivity 93.3%, specificity 100%) showed high accuracy in NASH diagnosis. CONCLUSION: TIMP-1 and TIMP-2 may be considered noninvasive markers for the diagnosis of NASH.
BACKGROUND/AIMS: Non-alcoholic fatty liver disease is a spectrum of clinical conditions, including simple steatosis and non-alcoholic steatohepatitis (NASH). The aim of the study is to evaluate the tissue inhibitors of metalloproteinase-1 and 2 (TIMPs) as noninvasive predictors of NASH. METHODS: Three groups were included in the study. Obesepatients (n = 30) with normal liver enzymes were included in group I and obesepatients (n = 30) with elevated liver enzymes with liver biopsy-based diagnosis of NASH were included in group II. Age-matched subjects (n = 30) formed the control as group III. The lipid profile, liver enzyme levels and levels of TIMPs were compared among all the patients and subjects. RESULTS: Comparison of groups I and II showed significantly elevated levels of TIMP-1 and TIMP-2 in group II as compared to group I (p < 0.05). Similarly, comparison between groups II and III showed significantly increased levels of TIMP-1 and TIMP-2 in group II as compared to group III (p < 0.05). TIMP-1 (sensitivity 96.7%, specificity 100%) and TIMP-2 (sensitivity 93.3%, specificity 100%) showed high accuracy in NASH diagnosis. CONCLUSION:TIMP-1 and TIMP-2 may be considered noninvasive markers for the diagnosis of NASH.
Authors: Giuseppina Palladini; Laura Giuseppina Di Pasqua; Marta Cagna; Anna Cleta Croce; Stefano Perlini; Barbara Mannucci; Antonella Profumo; Andrea Ferrigno; Mariapia Vairetti Journal: Int J Mol Sci Date: 2022-06-19 Impact factor: 6.208
Authors: Viera Kupčová; Michaela Fedelešová; Jozef Bulas; Petra Kozmonová; Ladislav Turecký Journal: Int J Environ Res Public Health Date: 2019-09-24 Impact factor: 3.390
Authors: Philipp Schwabl; Eva Hambruch; Grant R Budas; Paul Supper; Michael Burnet; John T Liles; Manfred Birkel; Ksenia Brusilovskaya; Philipp Königshofer; Markus Peck-Radosavljevic; William J Watkins; Michael Trauner; David G Breckenridge; Claus Kremoser; Thomas Reiberger Journal: Biomedicines Date: 2021-01-09
Authors: Francisco Javier Ruiz-Ojeda; Andrea Méndez-Gutiérrez; Concepción María Aguilera; Julio Plaza-Díaz Journal: Int J Mol Sci Date: 2019-10-02 Impact factor: 5.923