Literature DB >> 26329563

Disorder, not just state of risk: meta-analysis of functioning and quality of life in people at high risk of psychosis.

Paolo Fusar-Poli1, Matteo Rocchetti2, Alberto Sardella2, Alessia Avila2, Martina Brandizzi2, Edgardo Caverzasi2, Pierluigi Politi2, Stephan Ruhrmann2, Philip McGuire2.   

Abstract

BACKGROUND: The nosology of the psychosis high-risk state is controversial. Traditionally conceived as an 'at risk' state for the development of psychotic disorders, it is also conceptualised as a clinical syndrome associated with functional impairment. AIMS: To investigate meta-analytically the functional status of patients at high clinical risk for psychosis and its association with longitudinal outcomes.
METHOD: Three meta-analyses compared level of functioning (n = 3012) and quality of life (QoL) (n = 945) between a high-risk group, a healthy control group and group with psychosis, and baseline functioning in people in the high-risk group who did or did not have a transition to psychosis at follow-up (n = 654).
RESULTS: People at high risk had a large impairment in functioning (P<0.001) and worse QoL (P = 0.001) than the healthy control group, but only small to moderately better functioning (P = 0.012) and similar QoL (P = 0.958) compared with the psychosis group. Among the high-risk group, those who did not develop psychosis reported better functioning (P = 0.001) than those who did.
CONCLUSIONS: Our results indicate that the high-risk state is characterised by consistent and large impairments of functioning and reduction in QoL similar to those in other coded psychiatric disorders. © The Royal College of Psychiatrists 2015.

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Year:  2015        PMID: 26329563     DOI: 10.1192/bjp.bp.114.157115

Source DB:  PubMed          Journal:  Br J Psychiatry        ISSN: 0007-1250            Impact factor:   9.319


  74 in total

1.  At risk or not at risk? A meta-analysis of the prognostic accuracy of psychometric interviews for psychosis prediction.

Authors:  Paolo Fusar-Poli; Marco Cappucciati; Grazia Rutigliano; Frauke Schultze-Lutter; Ilaria Bonoldi; Stefan Borgwardt; Anita Riecher-Rössler; Jean Addington; Diana Perkins; Scott W Woods; Thomas H McGlashan; Jimmy Lee; Joachim Klosterkötter; Alison R Yung; Philip McGuire
Journal:  World Psychiatry       Date:  2015-10       Impact factor: 49.548

2.  Early language measures associated with later psychosis features in 22q11.2 deletion syndrome.

Authors:  Cynthia B Solot; Tyler M Moore; Terrence Blaine Crowley; Marsha Gerdes; Edward Moss; Daniel E McGinn; Beverly S Emanuel; Elaine H Zackai; Sean Gallagher; Monica E Calkins; Kosha Ruparel; Ruben C Gur; Donna M McDonald-McGinn; Raquel E Gur
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2020-07-27       Impact factor: 3.568

3.  Clinical high risk for psychosis in childhood and adolescence: findings from the 2-year follow-up of the ReARMS project.

Authors:  Michele Poletti; Lorenzo Pelizza; Silvia Azzali; Federica Paterlini; Sara Garlassi; Ilaria Scazza; Luigi Rocco Chiri; Eva Gebhardt; Simona Pupo; Raballo Andrea
Journal:  Eur Child Adolesc Psychiatry       Date:  2018-12-01       Impact factor: 4.785

4.  Attenuated Mismatch Negativity in Attenuated Psychosis Syndrome Predicts Psychosis: Can Galantamine-Memantine Combination Prevent Psychosis?

Authors:  Maju Mathew Koola
Journal:  Mol Neuropsychiatry       Date:  2018-06-07

5.  Beyond the "at risk mental state" concept: transitioning to transdiagnostic psychiatry.

Authors:  Patrick D McGorry; Jessica A Hartmann; Rachael Spooner; Barnaby Nelson
Journal:  World Psychiatry       Date:  2018-06       Impact factor: 49.548

6.  Why ultra high risk criteria for psychosis prediction do not work well outside clinical samples and what to do about it.

Authors:  Paolo Fusar-Poli
Journal:  World Psychiatry       Date:  2017-06       Impact factor: 49.548

7.  Improving outcomes of first-episode psychosis: an overview.

Authors:  Paolo Fusar-Poli; Patrick D McGorry; John M Kane
Journal:  World Psychiatry       Date:  2017-10       Impact factor: 49.548

8.  Baby or bathwater? Referrals of "non-cases" in a targeted early identification intervention for psychosis.

Authors:  Gerald Jordan; Miriam Kinkaid; Srividya N Iyer; Ridha Joober; Karen Goldberg; Ashok Malla; Jai L Shah
Journal:  Soc Psychiatry Psychiatr Epidemiol       Date:  2018-03-14       Impact factor: 4.328

9.  The Global Functioning: Social and Role Scales-Further Validation in a Large Sample of Adolescents and Young Adults at Clinical High Risk for Psychosis.

Authors:  Ricardo E Carrión; Andrea M Auther; Danielle McLaughlin; Ruth Olsen; Jean Addington; Carrie E Bearden; Kristin S Cadenhead; Tyrone D Cannon; Daniel H Mathalon; Thomas H McGlashan; Diana O Perkins; Larry J Seidman; Ming T Tsuang; Elaine F Walker; Scott W Woods; Barbara A Cornblatt
Journal:  Schizophr Bull       Date:  2019-06-18       Impact factor: 9.306

10.  Neuroanatomical Predictors of Functional Outcome in Individuals at Ultra-High Risk for Psychosis.

Authors:  Renate L E P Reniers; Ashleigh Lin; Alison R Yung; Nikolaos Koutsouleris; Barnaby Nelson; Vanessa L Cropley; Dennis Velakoulis; Patrick D McGorry; Christos Pantelis; Stephen J Wood
Journal:  Schizophr Bull       Date:  2017-03-01       Impact factor: 9.306

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