Natalia Simanovsky1, Shoshana Revel-Vilk2, Michael Weintraub2, Nurith Hiller3. 1. Department of Medical Imaging, Hadassah-Hebrew University Medical Center at Mt Scopus, POB 12000, Jerusalem, Israel, 91120. natalias@hadassah.org.il. 2. Department of Pediatric Hematology/ Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. 3. Department of Medical Imaging, Hadassah-Hebrew University Medical Center at Mt Scopus, POB 12000, Jerusalem, Israel, 91120.
Abstract
OBJECTIVES: Evaluate a potential association between Wilms' tumour (WT) and renal cystic lesions. METHODS: Digital records and imaging files of consecutive patients diagnosed with WT between 2004 and 2014 were retrospectively reviewed under an Institutional Review Board waiver of informed consent. The locations of renal cysts seen on US, CT, and/or MRI were recorded and compared with the locations of newly developed WT. RESULTS: A total of 48 patients (mean age 3 years 9 months) presented with newly diagnosed WT in the study period. Mean follow-up was 4.5 (range 1-10) years. WT was unilateral in 40 children, bilateral in 8. Renal cysts were identified in only one of the forty patients (2.5 %) with unilateral disease - in the contralateral kidney. In contrast, renal cysts were found in seven of eight patients with bilateral WT (87.5 %), in two of whom, new tumours developed in the same location where cysts had been seen on previous imaging studies. CONCLUSIONS: Renal cystic lesions in patients with Wilms' tumour should be regarded as potential tumour precursors, and followed with frequent imaging. KEY POINTS: • Cortical renal cystic lesions have a high association with bilateral Wilms' tumour. • In children with Wilms' tumour renal cysts are possible tumour precursors. • MRI appears to be the best modality in depicting the cortical cysts.
OBJECTIVES: Evaluate a potential association between Wilms' tumour (WT) and renal cystic lesions. METHODS: Digital records and imaging files of consecutive patients diagnosed with WT between 2004 and 2014 were retrospectively reviewed under an Institutional Review Board waiver of informed consent. The locations of renal cysts seen on US, CT, and/or MRI were recorded and compared with the locations of newly developed WT. RESULTS: A total of 48 patients (mean age 3 years 9 months) presented with newly diagnosed WT in the study period. Mean follow-up was 4.5 (range 1-10) years. WT was unilateral in 40 children, bilateral in 8. Renal cysts were identified in only one of the forty patients (2.5 %) with unilateral disease - in the contralateral kidney. In contrast, renal cysts were found in seven of eight patients with bilateral WT (87.5 %), in two of whom, new tumours developed in the same location where cysts had been seen on previous imaging studies. CONCLUSIONS:Renal cystic lesions in patients with Wilms' tumour should be regarded as potential tumour precursors, and followed with frequent imaging. KEY POINTS: • Cortical renal cystic lesions have a high association with bilateral Wilms' tumour. • In children with Wilms' tumour renal cysts are possible tumour precursors. • MRI appears to be the best modality in depicting the cortical cysts.
Authors: Elizabeth J Perlman; Paulo Faria; Andreia Soares; Fred Hoffer; Simone Sredni; Michael Ritchey; Robert C Shamberger; Daniel Green; J B Beckwith Journal: Pediatr Blood Cancer Date: 2006-02 Impact factor: 3.167
Authors: Thomas P Rauth; Jeremy Slone; Gabriella Crane; Hernan Correa; Debra L Friedman; Harold N Lovvorn Journal: J Pediatr Surg Date: 2011-05 Impact factor: 2.545
Authors: L H Lowe; B H Isuani; R M Heller; S M Stein; J E Johnson; O M Navarro; M Hernanz-Schulman Journal: Radiographics Date: 2000 Nov-Dec Impact factor: 5.333