Literature DB >> 26328447

How Sorbitan Monostearate Can Increase Drug-Loading Capacity of Lipid-Core Polymeric Nanocapsules.

Fernanda S Poletto, Catiúscia P De Oliveira, Heberton Wender, Dorothée Regent, Bruna Donida, Sérgio R Teixeira, Sílvia S Guterres, Bartira Rossi-Bergmann, Adriana R Pohlmann.   

Abstract

Lipid-core polymeric nanocapsules are innovative devices that present distinguished characteristics due to the presence of sorbitan monostearate into the oily-core. This component acted as low-molecular-mass organic gelator for the oil (medium chain triglycerides). The organogel-structured core influenced the polymeric wall characteristics disfavoring the formation of more stable polymer crystallites. This probably occurred due to interpenetration of these pseudo-phases. Sorbitan monostearate dispersed in the oily-core was also able to interact by non-covalent bonding with the drugs increasing the drug loading capacity more than 40 times compared to conventional nanocapsules. We demonstrated that the drug-models quercetin and quercetin pentaacetate stabilized the organogel network probably due to interactions of the drug molecules with the sorbitan monostearate headgroups by hydrogen bonding.

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Year:  2015        PMID： 26328447     DOI： 10.1166/jnn.2015.9182

Source DB:  PubMed          Journal:  J Nanosci Nanotechnol        ISSN： 1533-4880


  5 in total

1.  Surface-functionalized curcumin-loaded polymeric nanocapsules could block apomorphine-induced behavioral changes in rats.

Authors:  Camila de Oliveira Pacheco; Marcelo Gomes de Gomes; Manoel Rodrigues da Silva Neto; Alcides José Martins Parisotto; Renata Bem Dos Santos; Tamara Ramos Maciel; Ana Cláudia Funguetto Ribeiro; Renata Giacomeli; Sandra Elisa Haas
Journal:  Pharmacol Rep       Date:  2021-11-05       Impact factor: 3.024

2.  Caenorhabditis elegans as an alternative in vivo model to determine oral uptake, nanotoxicity, and efficacy of melatonin-loaded lipid-core nanocapsules on paraquat damage.

Authors:  Mariele Feiffer Charão; Caroline Souto; Natália Brucker; Anelise Barth; Denise S Jornada; Daiandra Fagundez; Daiana Silva Ávila; Vera L Eifler-Lima; Silvia S Guterres; Adriana R Pohlmann; Solange Cristina Garcia
Journal:  Int J Nanomedicine       Date:  2015-08-10

3.  Labeling the oily core of nanocapsules and lipid-core nanocapsules with a triglyceride conjugated to a fluorescent dye as a strategy to particle tracking in biological studies.

Authors:  Luana Almeida Fiel; Renata Vidor Contri; Juliane Freitas Bica; Fabrício Figueiró; Ana Maria Oliveira Battastini; Sílvia Stanisçuaski Guterres; Adriana Raffin Pohlmann
Journal:  Nanoscale Res Lett       Date:  2014-05-13       Impact factor: 4.703

4.  Methotrexate-loaded lipid-core nanocapsules are highly effective in the control of inflammation in synovial cells and a chronic arthritis model.

Authors:  Antônio Luiz Boechat; Catiúscia Padilha de Oliveira; Andrea Monteiro Tarragô; Allyson Guimarães da Costa; Adriana Malheiro; Silvia Stanisçuaski Guterres; Adriana Raffin Pohlmann
Journal:  Int J Nanomedicine       Date:  2015-10-22

5.  Effects of Two Types of Melatonin-Loaded Nanocapsules with Distinct Supramolecular Structures: Polymeric (NC) and Lipid-Core Nanocapsules (LNC) on Bovine Embryo Culture Model.

Authors:  Eliza Rossi Komninou; Mariana Härter Remião; Caroline Gomes Lucas; William Borges Domingues; Andrea Cristina Basso; Denise Soledade Jornada; João Carlos Deschamps; Ruy Carlos Ruver Beck; Adriana Raffin Pohlmann; Vilceu Bordignon; Fabiana Kömmling Seixas; Vinicius Farias Campos; Silvia Stanisçuaski Guterres; Tiago Collares
Journal:  PLoS One       Date:  2016-06-16       Impact factor: 3.240
  5 in total

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