Literature DB >> 26327434

Helical peptaibol mimics are better ionophores when racemic than when enantiopure.

Sarah J Pike1, Jennifer E Jones, James Raftery, Jonathan Clayden, Simon J Webb.   

Abstract

Helical peptide foldamers rich in α-aminoisobutyric acid (Aib) act as peptaibol-mimicking ionophores in the phospholipid bilayers of artificial vesicles. Racemic samples of these foldamers are more active than their enantiopure counterparts, which was attributed to differing propensities to form aggregates with crystal-like features in the bilayer.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 26327434     DOI： 10.1039/c5ob01652e

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  3 in total

1.  Length-Dependent Formation of Transmembrane Pores by 310-Helical α-Aminoisobutyric Acid Foldamers.

Authors:  Jennifer E Jones; Vincent Diemer; Catherine Adam; James Raftery; Rebecca E Ruscoe; Jason T Sengel; Mark I Wallace; Antoine Bader; Scott L Cockroft; Jonathan Clayden; Simon J Webb
Journal:  J Am Chem Soc       Date:  2016-01-08       Impact factor: 15.419

2.  α-Amino-iso-Butyric Acid Foldamers Terminated with Rhodium(I) N-Heterocyclic Carbene Catalysts.

Authors:  David P Tilly; William Cullen; Heng Zhong; Romain Jamagne; Inigo Vitórica-Yrezábal; Simon J Webb
Journal:  Chemistry       Date:  2022-01-12       Impact factor: 5.020

3.  Insight into the Mechanism of Action and Peptide-Membrane Interactions of Aib-Rich Peptides: Multitechnique Experimental and Theoretical Analysis.

Authors:  Maria Giovanna Lizio; Mario Campana; Matteo De Poli; Damien F Jefferies; William Cullen; Valery Andrushchenko; Nikola P Chmel; Petr Bouř; Syma Khalid; Jonathan Clayden; Ewan Blanch; Alison Rodger; Simon J Webb
Journal:  Chembiochem       Date:  2021-02-24       Impact factor: 3.164
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.