Literature DB >> 26323877

Hepatitis: Epigenetic control of HBV by HBx protein--releasing the break?

Ulrike Protzer1.   

Abstract

HBV persists by depositing covalently closed circular DNA (cccDNA) into the nucleus of infected host cells. HBV X protein (HBx) is a crucial determinant for regulating HBV activity, but the molecular details have not been fully understood. A new role for HBx in regulating cccDNA transcription has now been identified.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 26323877     DOI： 10.1038/nrgastro.2015.152

Source DB:  PubMed          Journal:  Nat Rev Gastroenterol Hepatol        ISSN： 1759-5045            Impact factor:   46.802


  10 in total

1.  Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function.

Authors:  Laura Belloni; Teresa Pollicino; Francesca De Nicola; Francesca Guerrieri; Giuseppina Raffa; Maurizio Fanciulli; Giovanni Raimondo; Massimo Levrero
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-11       Impact factor: 11.205

2.  Structural organization of the hepatitis B virus minichromosome.

Authors:  C T Bock; S Schwinn; S Locarnini; J Fyfe; M P Manns; C Trautwein; H Zentgraf
Journal:  J Mol Biol       Date:  2001-03-16       Impact factor: 5.469

3.  HBx protein is indispensable for development of viraemia in human hepatocyte chimeric mice.

Authors:  Masataka Tsuge; Nobuhiko Hiraga; Rie Akiyama; Sachi Tanaka; Miyuki Matsushita; Fukiko Mitsui; Hiromi Abe; Shosuke Kitamura; Tsuyoshi Hatakeyama; Takashi Kimura; Daiki Miki; Nami Mori; Michio Imamura; Shoichi Takahashi; C Nelson Hayes; Kazuaki Chayama
Journal:  J Gen Virol       Date:  2010-03-10       Impact factor: 3.891

4.  HBx relieves chromatin-mediated transcriptional repression of hepatitis B viral cccDNA involving SETDB1 histone methyltransferase.

Authors:  Lise Rivière; Laetitia Gerossier; Aurélie Ducroux; Sarah Dion; Qiang Deng; Marie-Louise Michel; Marie-Annick Buendia; Olivier Hantz; Christine Neuveut
Journal:  J Hepatol       Date:  2015-07-02       Impact factor: 25.083

5.  Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection.

Authors:  Julie Lucifora; Silke Arzberger; David Durantel; Laura Belloni; Michel Strubin; Massimo Levrero; Fabien Zoulim; Olivier Hantz; Ulrike Protzer
Journal:  J Hepatol       Date:  2011-03-02       Impact factor: 25.083

Review 6.  The mammalian epigenome.

Authors:  Bradley E Bernstein; Alexander Meissner; Eric S Lander
Journal:  Cell       Date:  2007-02-23       Impact factor: 41.582

7.  Woodchuck hepatitis virus X protein is required for viral infection in vivo.

Authors:  F Zoulim; J Saputelli; C Seeger
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103

8.  A concerted action of HNF4alpha and HNF1alpha links hepatitis B virus replication to hepatocyte differentiation.

Authors:  Maria Quasdorff; Marianna Hösel; Margarete Odenthal; Uta Zedler; Felix Bohne; Philippe Gripon; Hans-Peter Dienes; Uta Drebber; Dirk Stippel; Tobias Goeser; Ulrike Protzer
Journal:  Cell Microbiol       Date:  2008-03-11       Impact factor: 3.715

9.  Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones.

Authors:  Teresa Pollicino; Laura Belloni; Giuseppina Raffa; Natalia Pediconi; Giovanni Squadrito; Giovanni Raimondo; Massimo Levrero
Journal:  Gastroenterology       Date:  2006-03       Impact factor: 22.682

10.  A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery.

Authors:  Ti Li; Eva I Robert; Pieter C van Breugel; Michel Strubin; Ning Zheng
Journal:  Nat Struct Mol Biol       Date:  2009-12-06       Impact factor: 15.369
  10 in total
  5 in total

1.  Hepatitis B virus X protein is capable of down-regulating protein level of host antiviral protein APOBEC3G.

Authors:  Ruidong Chen; Xue Zhao; Yongxiang Wang; Youhua Xie; Jing Liu
Journal:  Sci Rep       Date:  2017-01-18       Impact factor: 4.379

2.  Downregulated long non-coding RNA DREH promotes cell proliferation in hepatitis B virus-associated hepatocellular carcinoma.

Authors:  Dong Lv; Yuan Wang; Ying Zhang; Peilin Cui; Youqing Xu
Journal:  Oncol Lett       Date:  2017-06-21       Impact factor: 2.967

Review 3.  A Role for the Host DNA Damage Response in Hepatitis B Virus cccDNA Formation-and Beyond?

Authors:  Sabrina Schreiner; Michael Nassal
Journal:  Viruses       Date:  2017-05-22       Impact factor: 5.048

4.  Anti-Hepatitis B Virus Activity of Esculetin from Microsorium fortunei In Vitro and In Vivo.

Authors:  Si-Xin Huang; Jun-Fei Mou; Qin Luo; Qing-Hu Mo; Xian-Li Zhou; Xiao Huang; Qing Xu; Xiang-Duan Tan; Xu Chen; Cheng-Qin Liang
Journal:  Molecules       Date:  2019-09-25       Impact factor: 4.411

5.  Characterization and engineering of broadly reactive monoclonal antibody against hepatitis B virus X protein that blocks its interaction with DDB1.

Authors:  Shuai Tao; Shaokun Pan; Chenjian Gu; Lili Wei; Ning Kang; Youhua Xie; Jing Liu
Journal:  Sci Rep       Date:  2019-12-30       Impact factor: 4.379
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.