Fatemeh Shahsavari1, Sareh Farhadi2, Donia Sadri1, Marzieh Sedehi3. 1. Department of Oral and Maxillofacial Pathology, Dental Branch of Tehran, Islamic Azad University, Tehran, Iran. 2. Assistant Professor, Department of Oral and Maxillofacial Pathology, Dental Branch of Tehran, Islamic Azad University, No. 177, Fifth Golestan St, Pasdaran St, Tehran, Iran, Phone: +98 21 22542238, e-mail: dr.sfarhadi@gmail.com. 3. Private Practice, Tehran, Iran.
Abstract
AIM: The present study was scheduled to evaluate microvascularity by CD34 expression in esophagus and oral squamous cell carcinoma. MATERIALS AND METHODS: This study was scheduled using 40 paraffin blocked samples including 20 of oral SCC and 20 of esophagus ones and Immunohistochemical staining was conducted using CD34 monoclonal antibody. Exact fisher test was used to evaluate frequency of expression between two studied groups. RESULTS: There was significant correlation between age and tumor size with CD34 expression in oral SCC samples (p < 0.05) and no significant correlation between sex and tumor differentiation level (grading) (p > 0.05). Also, there was no significant correlation between age, sex, tumor size and tumor differentiation level (grading) with CD34 expression in esophagus SCC samples (p > 0.05). There was no significant difference of CD34 expression frequency in oral and esophagus SCC (p = 0/583). Finally, CD34 expression was reported 'high' for major cases of esophagus and oral SCCs. CONCLUSION: It seems, other angiogenetic or nonangiogenetic factors except CD34 may play more important role and explain the different clinical behavior of SCC at recent different locations. CLINICAL SIGNIFICANCE: Other factors would be considered along with CD34 expression to interpret different clinical behavior of SCC at recent different locations.
AIM: The present study was scheduled to evaluate microvascularity by CD34 expression in esophagus and oral squamous cell carcinoma. MATERIALS AND METHODS: This study was scheduled using 40 paraffin blocked samples including 20 of oral SCC and 20 of esophagus ones and Immunohistochemical staining was conducted using CD34 monoclonal antibody. Exact fisher test was used to evaluate frequency of expression between two studied groups. RESULTS: There was significant correlation between age and tumor size with CD34 expression in oral SCC samples (p < 0.05) and no significant correlation between sex and tumor differentiation level (grading) (p > 0.05). Also, there was no significant correlation between age, sex, tumor size and tumor differentiation level (grading) with CD34 expression in esophagus SCC samples (p > 0.05). There was no significant difference of CD34 expression frequency in oral and esophagus SCC (p = 0/583). Finally, CD34 expression was reported 'high' for major cases of esophagus and oral SCCs. CONCLUSION: It seems, other angiogenetic or nonangiogenetic factors except CD34 may play more important role and explain the different clinical behavior of SCC at recent different locations. CLINICAL SIGNIFICANCE: Other factors would be considered along with CD34 expression to interpret different clinical behavior of SCC at recent different locations.