Literature DB >> 26322986

Correction: An Improved Method for P2X7R Antagonist Screening.

Rômulo José Soares-Bezerra, Natiele Carla da Silva Ferreira, Anael Viana Pinto Alberto, André Gustavo Bonavita, Antônio Augusto Fidalgo-Neto, Andrea Surrage Calheiros, Valber da Silva Frutuoso, Luiz Anastacio Alves.   

Abstract

Entities:  

Year:  2015        PMID： 26322986      PMCID： PMC4556455          DOI： 10.1371/journal.pone.0137488

Source DB:  PubMed          Journal:  PLoS One        ISSN： 1932-6203            Impact factor:   3.240


× No keyword cloud information.
There are errors in the seventh sentence of the Abstract. Specifically, the values provided for ATP, BBG and OATP are incorrect. The correct sentence is: The values obtained were consistent with those found in the literature (0.7 ± 0.07 mM, 1.3–2.6 μM and 173–285 μM for ATP, BBG and OATP, respectively). Additionally, there are errors in the units of Table 1. The correct units for columns BBG (IC50) and OATP (IC50) are μM. Please see the corrected Table 1 here.
Table 1

IC50 or EC50 values for P2X7R agonists or antagonists using different methods.

ATP (EC50)BBG (IC50)* OATP (IC50)Reference
Cytometry2–4 mMN.D.** 300 μMCoddou et al. 2011
Electrophysiology2–4 mMN.D.***300 μMCoddou et al. 2011
FLIPRN.D.** 6.71±0.05 μMN.D.** Namovic et al. 2012
Spectrophotometry0.7 ±0.07 mM1.3–2.6 μM173–285 μMPresent study

*IC50 for natively expressed mP2X7R in J774.G8 cells.

**N.D. = Not determined

*IC50 for natively expressed mP2X7R in J774.G8 cells. **N.D. = Not determined
  1 in total

1.  An Improved Method for P2X7R Antagonist Screening.

Authors:  Rômulo José Soares-Bezerra; Natiele Carla da Silva Ferreira; Anael Viana Pinto Alberto; André Gustavo Bonavita; Antônio Augusto Fidalgo-Neto; Andrea Surrage Calheiros; Valber da Silva Frutuoso; Luiz Anastacio Alves
Journal:  PLoS One       Date:  2015-05-19       Impact factor: 3.240
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.