Literature DB >> 2632217

Synthesis and antitumour activity of 4-nitroso-4-(2-chloroethyl)semicarbazides.

R G Gugova1, Z D Raikov, S G Zakhariev, G D Demirov, D K Todorov, M V Ilarionova.   

Abstract

1-Methyl-1-(2-chloroethyl)-4-nitroso-4-(2-chloroethyl)semicarbazide, 1,1-di-(2-chloroethyl)-4-nitroso-4-(2-chloroethyl)semicarbazide and 1,1-di-(2-bromoethyl)-4-nitroso-4-(2-chloroethyl)semicarbazide, which are a novel class of nitrosoureas containing hydrazinomustard residue, have been synthesized. A dose-dependent antitumour activity was found with the three tested compounds.

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Year:  1989        PMID: 2632217

Source DB:  PubMed          Journal:  Drugs Exp Clin Res        ISSN: 0378-6501


  1 in total

1.  Mutagenic activity of some newly synthesized cytostatic 1-(2-chloroethyl)-4-arylacyl-1-nitrososemicarbazides in the Salmonella/mammalian microsome assay.

Authors:  E Golovinsky; R Gugova; K Norpoth; E Mohtashamipur
Journal:  J Cancer Res Clin Oncol       Date:  1991       Impact factor: 4.553

  1 in total

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